Zebrafish International Resource Center

斑马鱼已经成为研究脊椎动物发育和遗传学的首要生物。强大 技术允许有效地产生和恢复影响调节基因的斑马鱼突变 发育模式、器官发生、生理学和行为。最新的进展使得 研究转基因斑马鱼基因功能和反义寡核苷酸。许多功能 这些基因在脊椎动物群体中是保守的。因此，对斑马鱼突变的分析提供了 深入了解其他脊椎动物的基因功能，包括人类。 斑马鱼国际资源中心已经建立，作为一个储存库，提供动物， 为研究界提供材料和服务。该提案寻求持续的资金1）提供一个 斑马鱼遗传资源和研究材料的中央储存库，2）提供咨询， 病理学服务，以及3）开发改进的斑马鱼饲养方法。这些材料、服务 并向研究界广泛提供信息。

Zebrafish has emerged as a premiere organism to study vertebrate development and genetics. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The Zebrafish International Resource Center has been established as a repository that provides animals, materials and services to the research community. This proposal seeks continued funding 1) to provide a centralized repository for zebrafish genetic stocks and research materials, 2) to provide consultation and pathology services, and 3) to develop improved zebrafish husbandry methods. These materials, services and information will be made widely available to the research community.