Human Genetic Analysis Resource

这一人类遗传分析资源将有助于识别、绘制和表征 导致人类复杂疾病的基因。该资源将在人力资源方面提供服务和专业知识 对调查此类疾病的家族性的研究人员进行基因分析。进一步统计 将为此目的开发分析和研究设计的方法，并有良好的文件记录和用户友好 编写的计算机程序，可以很容易地根据其他人类遗传学家的需要进行定制 和流行病学家。理论发展将包括对所有人的有效性、力量和稳健性的研究 制定了程序。关联、分离和连锁分析的方法将允许例如非正态， 多因素导致的家庭相关性，测量和未测量的环境影响， 孟德尔和非孟德尔的遗传效应，以及非随机抽样。中国的咨询服务 将提供这些方法的使用，并将这些方法应用于几个合作研究 广泛的领域，包括癌症、肺/心血管疾病、眼科疾病、神经学 疾病、自身免疫性疾病和肾脏疾病。 人类基因分析员将接受博士后和博士后阶段的培训，并提供短期课程， 在国内和国际上，培训遗传流行病学统计分析人员和 使用将要开发的计算机程序。有关资源及其活动的信息将 在国家和国际会议上广泛传播，并在 万维网。

This Human Genetic Analysis Resource will facilitate the identification, mapping and characterization of genes that cause complex diseases in man. The Resource will provide services and expertise in human genetic analysis to research workers investigating the familial nature of such diseases. Further statistical methods of analysis and study designs will be developed for this purpose, and well-documented, userfriendly computer programs prepared that can be easily tailored to the needs of other human geneticists and epidemiologists. Theoretical developments will include studies of validity, power and robustness of all procedures developed. Methods of association, segregation and linkage analysis will allow for, e.g., nonnormality, multifactorially caused familial correlations, measured and non-measured environmental effects, both Mendelian and non-Mendelian genetic effects, and non-random sampling. Consulting services in the use of these methods will be provided, and the methods will be applied in collaborative research to several broad areas, including cancer, pulmonary/ cardiovascular diseases, ophthalmologic diseases, neurological diseases, autoimmune diseases, and renal diseases. Human genetic analysts will be trained at the pre- and post-doctoral levels, and short courses given, both nationally and internationally, to train people in statistical analysis for genetic epidemiology and in the use of the computer programs that will be developed. Information about the Resource and its activities will be broadly disseminated at national and international meetings and by maintaining a home page on the World Wide Web.