SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER

拨款P51 RR00163-45的5年续期申请为支持ONPRC生物医学研究的项目提供资金。该申请反映了动物资源和研究服务核心的显著扩展，这是支持研究项目增长所需的（外部资助资金在过去5年中翻了一番），并大大扩展了印度衍生的无特定病原体（SPF）恒河猴繁殖群。该申请的目的是：1)为开展先进生物医学研究提供必要的基础设施支持，这些研究使用非人类灵长类动物（NHPs）来加速了解人类疾病的进展，从而改善健康状况；2)加强中心资源（科学专业知识、实验室、动物服务、研究服务核心和设备），发挥区域、国家和国际资源的作用；3)通过支持我们的项目扩大SPF印度衍生恒河猴育种项目，增加生物医学研究中定义的NHPs的可用性，该项目生产的动物没有B型疱疹等病毒，并具有明确的亲代和基因型；4)扩大利用NHPs在遗传学、传染病和疫苗开发、老龄化、神经科学和妇女健康方面的研究项目。为了实现这些目标，要求在四个广泛领域提供支助。行政和中心运营部门为ONPRC的各个方面提供所需的行政和服务支持。单位包括主任办公室，商务服务，设施和财产，以及信息技术和工程。研究基础设施包括提供技术最先进的研究支持的服务单位，如动物资源（业务和研究协调、临床医学、NHP资源、手术、病理服务、心理健康和外科服务）、研究服务核心(辅助生殖技术、电生理学、内分泌服务、流式细胞术、成像和形态学、分子和细胞生物学、单克隆抗体、研究图书馆和病毒学)和特殊资源计划（替代NHP物种，遗传资源和信息学，老龄化NHP和恒河猴育种）。科学资源包括对ONRPC科学家所在的三个研究部门的支持：病理生物学和免疫学、免疫学、神经科学和生殖科学部门。4个资源相关研究项目和试点项目也需要资金支持。改进和现代化包括用于设备、改造和翻新的资金。

The 5-year renewal for Grant P51 RR00163-45 requests funding for programs that support biomedical research at the ONPRC. The application reflects a significant expansion in animal resources and research service cores that is required to support the growth in research programs (external grant funding has doubled during the past 5 years) and to greatly expand the Specific Pathogen Free (SPF) Indian-derived Rhesus Breeding Colony. The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which nonhuman primates (NHPs) are used to accelerate progress in understanding human diseases, leading to better health; 2) enhance the Center's resources (scientific expertise, laboratories, animal services, research service cores and equipment) so as to serve as a regional, national and international resource; 3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-derived Rhesus macaque breeding program that produces animals free of viruses such as herpes B and with defined parentage and genotype; and 4) expand research programs utilizing NHPs in genetics, infectious diseases and vaccine development, aging, neuroscience and women's health. To accomplish these aims, support is requested in four broad areas. Administration and Center Operations provide the administrative and service support that is required for all aspects of the ONPRC. Units include the Director's Office, Business Services, Facilities and Property, and Information Technology and Engineering. Research Infrastructure encompasses the service units that provide the most technologically advanced research support, such as Animal Resources (Business and Research Coordination, Clinical Medicine, NHP Resources, Operations, Pathology Services, Psychological Well Being and Surgery Services), Research Service Cores (Assisted Reproductive Technology, Electrophysiology, Endocrine Services, Flow Cytometry, Imaging and Morphology, Molecular and Cellular Biology, Monoclonal Antibody, Research Library, and Virology) and Special Resources Programs (Alternative NHP Species, Genetics Resource and Informatics, Aging NHPs and Rhesus Breeding). Scientific Resources includes support for the three research divisions that house ONRPC scientists: the Divisions of Pathobioloqy and Immunolo,qy, Neuroscience, and Reproductive Sciences. Funding is also requested for 4 resource-related research projects and the pilot project program. Improvement and Modernization includes funds for equipment and alterations and renovations.