BIOSTATISTICS AND INFORMATICS SHARED RESOURCE

生物统计与信息共享资源(BISR)提供生物统计与信息资源 致德克萨斯大学健康科学中心癌症治疗和研究中心(P30) 圣安东尼奥(UTHSCSA)。这种集中式共享资源为以下各项提供灵活、经济高效的服务 通过为基础、跨领域、临床和大众研究人员提供生物统计学咨询 研究设计、研究结果的统计分析和解释以及数据支持 收集和信息管理。BISR维护癌症中心的信息基础设施 并协助个人调查人员或团体进行数据库设计、数据安全和研究 计算需求。BISR为研究办公室的数据管理人员提供支持 行政管理委员会(ORA)。信息学解决方案简化了许多监管操作，如质量 保证审查、不良事件自动报告和应计项目监控。BISR生物统计学家 是议定书审查委员会和数据安全监测委员会的积极成员。 该共享资源的具体功能包括：协议开发支持、质量保证、 统计分析、基于计算机的数据管理支持以及对教育使命的支持 癌症中心的研究人员。 BISR通过提供生物科技咨询，促进了新研究投资的发展 在研究设计和协议开发以及计算资源需求的确定方面。服务包括 以响应个别研究人员需求的方式提供，同时优化共同使用 我们在安火癌症中心的共享资源。 在目前的赠款期间，我们成功地招募了一支不同的核心生物统计学家团队，他们是 我们完整地参与了P30的所有研究计划，开发并实施了一种状态-- ART信息管理系统支持癌症研究，我们已经开始开发强大的 生物信息支持能力将通过将caBIG工具集成到我们的 研究信息学基础设施。

The Biostatistics and Informafics Shared Resource (BISR) provides biostafisfics and informafics resources to the Cancer Therapy and Research Center (P30) at the University of Texas Health Science Center at San Antonio (UTHSCSA). This centralized shared resource provides flexible, cost-efficient services to basic, translafional, clinical and populafion-based researchers by providing biostatisfical consultation in study design, stafistical analysis and interpretation of research findings as well as support for data collecfion and informafion management. The BISR maintains the cancer center informafics infrastructure and assists individual investigators or groups with the database design, data security, and research compufing needs. The BISR supports the data management personnel of the Office of Research Administrafion (ORA). Informatics solufions have streamlined many regulatory opei^afions such as quality assurance review, automated reporting of adverse events, and accrual monitoring. BISR biostatisticians are active members of the Protocol Review Committee and the Data Safety Monitoring Committee. The specific functions of this shared resource include: protocol development support, quality assurance, stafistical analysis, computer-based data management support, and support for the educafional mission of cancer center researchers. The BISR facilitates the development of new research invesfigations by providing biostafisfics consultafion in study design and protocol development and determinafion of computing resources needs. Services are provided in a manner responsive to the needs of individual researchers while opfimizing the common use of our shared resources across the enfire cancer center. In the current grant period, we successfully recruited a diverse team of core biostatisticians who are integrally involved in all of the research programs of the P30, we developed and implemented a state-ofthe- art informafion management system to support cancer research, and we have begun to develop strong bioinformafics support capabilifies which will be strengthened by the integrafion of caBIG tools into our research informatics infrastructure.