THE ULTASTRUCTURAL LOCALIZATION OF MINERAL WITHIN THE COLLAGEN FIBRIL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 我们先前已经证明，肌腱和脱矿骨在37 ℃孵育时迅速重新钙化。大鼠血清中的C（1）。 本研究的目的是检查在血清中孵育期间沉积到这些1型胶原基质中的初始矿物质的超微结构位置。 我们的工作假设是，初始矿物质将沉积在胶原纤维的孔区域内，如在体内矿化的初始阶段所见。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously shown that tendon and demineralized bone re-calcify rapidly when incubated at 37C in rat serum (1). The objective of the present study is to examine the ultrastructural location of the initial mineral deposited into these type 1 collagen matrices during incubation in serum. Our working hypothesis is that the initial mineral will be deposited within the hole region of the collagen fibril, as has been seen in the initial stages of mineralization in vivo.