CARCINOGENESIS PROGRAM

致癌(CA)计划的中心主题是研究分子和细胞机制 潜在的癌症发生和发展，目的是将所获得的知识应用于诊断， 癌症的预防和治疗。重点领域包括DNA损伤反应的各个方面，病毒 癌症发生和癌症模型。 计划成员：在过去的六年中，该计划的成员经历了一些 重大变化。这些变化是多种因素共同作用的结果。其中一个因素是 调动计划成员以帮助现有计划(例如，沃特曼博士将成为 生长因素和信号传递计划)或建立新的计划(例如，Nalcioglu博士将成为联合 肿瘤学成像和光谱计划的领导人)。另一个因素是2006年底决定 解散病毒学计划，并纳入那些致力于病毒致癌方面的成员 加入致癌计划。这些因素，以及其他教师流动率，都导致了 新增教职员工17人，正式成员总数为28人。相比之下，会员人数为20人。 2002年成为正式会员。目前，该委员会的成员分布在以下学校的13个部门 医学、生物科学和物理科学。癌症中心大力支持 在过去的筹资期间招募了几名新成员。这些人包括汉斯-乌尔里希·伯纳德，伊娃 Lee和Dominik Wodarz。值得注意的是，两名成员英格丽德·鲁夫和多米尼克·沃达兹 通过主校区提供给癌症中心的FTE招募到UCI。最近的一次 招募人员是谢尔盖·格兰多，他是一名资金雄厚的资深调查员，他带来了亚硝胺引发的专业知识 致癌。 CA计划有28名成员，代表12个部门和3所学校，在 与癌症相关的直接同行审查资助，其中10个项目由NCI资助，直接总数为 3025,379美元。2007年，会员共出版了74份出版物，其中48份与癌症有关。 其中25%是内部关系，8%是内部关系。

The central theme of the Carcinogensis (CA) Program is to investigate molecular and cellular mechanisms underlying cancer initiation and progression, with the goal of applying the knowledge gained to the diagnosis, prevention, and treatment of cancer. Focus areas include various aspects of DNA damage response, viral carcinogenesis, and cancer modeling. Program Membership: During the past six years, the membership of this Program has undergone some significant changes. These changes have been the consequence of a variety of factors. One factor was the transfer of Program Members to either aid existing Programs (e.g., Dr. Waterman to become Co-Leader of the Growth Factors & Signaling Program) or establish new Programs (e.g., Dr. Nalcioglu to become Co- Leader of the Onco-lmaging & Spectroscopy Program). Another factor was the decision in late 2006 to disband the Virology Program and incorporate those members working on aspects of viral carcinogenesis into the Carcinogenesis Program. These factors, as well as other faculty turnover, have resulted in the addition of 17 new faculty for a total Membership of 28 full Members. This compares to a membership of 20 full Members in 2002. Currently, the membership is spread over 13 Departments within the Schools of Medicine, Biological Sciences, and Physical Sciences. The Cancer Center has significantly supported the recruitment of several new Members over the past funding period. These include Hans-Ulrich Bernard, Eva Lee, and Dominik Wodarz. It is to be noted that two Members, Ingrid Ruf and Dominik Wodarz, were recruited to UCI through FTEs that were provided to the Cancer Center by the main campus. A very recent recruit is Sergei Grando, a senior and well-funded investigator who brings expertise in nitrosamine-initiated carcinogenesis. The CA Program has 28 Members representing 12 Departments and three Schools, and has $5,910,891 in direct cancer-related peer-reviewed funding, 10 projects of which are funded by NCI for a direct total of $3,025,379. In 2007, Members published a total of 74 publications with 48 of those being cancer-related of which 25% were inter- and 8% were intra-related.