STRUCTURAL MOLECULAR BIOLOGY PROGRAM

结构分子生物学(SM)计划的中心主题是利用现代方法 对重要的癌症相关问题进行化学和生化结构分析，以及在使用 指导新型化疗药物合成的结构信息。这一观点尤其值得注意 在已知促癌过程的分子方面的翻译领域很重要。这个 SM计划的近期目标是确定最终可能在以下方面取得进展的有用系统 癌症治疗，并利用现有的各种技术对其进行分析。这意味着要推导出 氨基酸侧链在酶活性部位的排列，遵循蛋白质的动态 构象对配基结合的响应，描绘了设计所需的关键特征 基于抗体的药物，或描述致癌病毒建立在其上的体系结构。功能 其次是结构，而功能的改变是治疗的核心。 SM计划有19名成员，代表6个部门和5所学校，在 与癌症相关的直接同行评审资助，其中一个项目由NCI资助，直接总额为 249,099美元。2007年，会员共出版了55本刊物，其中24本与癌症有关。 其中33%是内部关系，8%是内部关系。

The central theme of the Structural Molecular Biology (SM) Program is to utilize the modern methods of chemical and biochemical structural analysis to important cancer-related problems, as well as in using the structural information to direct the synthesis of novel chemotherapeutics. This perspective is especially important in translational areas in which molecular aspects of the cancer-promoting process are known. The immediate goals of the SM Program are to identify useful systems that might ultimately lead to advances in cancer treatment, and to analyze them using the range of technologies available. This means deducing the arrangement of amino acid side chains in the active sites of enzymes, following the dynamics of protein conformation in response to ligand binding, delineating the crucial characteristics necessary for the design of antibody-based drugs, or describing the architectures on which oncogenic viruses are founded. Function follows from structure, and modification of function lies at the heart of therapy. The SM Program has 19 Members, representing six Departments and five Schools, and has $2,615,535 in direct cancer-related peer-reviewed funding, one project of which is funded by NCI for a direct total of $249,099. In 2007, Members published a total of 55 publications with 24 of those being cancer-related of which 33% were inter- and 8% were intra-related.