NEUROSCIENCE AND METABOLIC DISORDERS PROJECT

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 由神经和/或代谢系统失调引起的公共卫生问题对埃尔帕索及其周边社区的居民来说非常重要。德克萨斯大学埃尔帕索分校（UTEP）是美国首屈一指的少数民族服务机构。墨西哥边境，有一个强大的基础研究计划，使我们的边境生物医学研究中心（BBRC）的RCMI支持成为可能。在BBRC内，神经科学和代谢障碍项目（NMDP）致力于合作研究，调查导致该地区高度表达的复杂疾病的神经和代谢机制。我们的愿景是，在我们提出的新研究主题（神经和代谢失调，神经毒理学，神经变性和恢复，细胞机制和癌症）下，正在进行的和新的合作以及试点研究赠款，将促进多学科研究，并允许未来的转化研究到治疗和干预边缘相关的健康状况，如抑郁症，成瘾，糖尿病和肥胖症，和癌症。NMDP的科学家通过使用包含专用设备和技术支持的优秀核心设施来提高生产力。研究人员和项目有机会变得更加成熟，并朝着不可能的方向发展，这些机会将来自拟议的活动。新的教职员工将建立在通过独立项目，试点研究赠款和核心设施的使用获得的势头上，促进NMDP内部以及NMDP与其他BBRC项目（毒理学，传染病和免疫学）之间的协同作用和扩展。这一新的研究战略的积极成果将是：1）在确保校外资金的成功增加; 2）在我们对RCMI基金的依赖同时减少; 3）多研究者和/或计划项目类型的补助金申请的开发和追求;和4）一个富有成效的环境，培训来自代表性不足的群体的年轻科学家。通过这项研究计划，我们将实现我们的使命，为埃尔帕索/华雷斯城社区的人们的健康和教育以及NIH和NCRR的使命做出重大贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Public health issues that result from nervous and/or metabolic system dysregulation are highly significant for the residents of El Paso and its surrounding communities. The University of Texas at El Paso (UTEP), a premier minority-serving institution on the U.S./Mexico border, has a robust basic research program made possible by the RCMI support of our Border Biomedical Research Center (BBRC). Within the BBRC the Neuroscience and Metabolic Disorders Project (NMDP) pursues collaborative research that investigates neurological and metabolic mechanisms that contribute to complex diseases that are highly expressed in this region. Our vision is that ongoin and new collaborations, and pilot research grants under our proposed new themes for research (neurological and metabolic dysregulation, neurotoxicology, neurodegeneration and recovery, and cellular mechanisms and cancer), will promote multidisciplinary research and permit future translational studies into therapeutics and interventions for border-relevant health conditions such as depression, addiction, diabetes and obesity, and cancer. Scientists in the NMDP enhance their productivity through the use of outstanding Core facilities which contain specilized equipment and technical support. Opportunities for investigators and programs to become more established and move in directions that likely would not otherwise be possible will result from the proposed activities. New faculty hires will build on the momentum gained through independent projects, pilot research grants and the use of the Core facilities, promoting synergy and expansion within the NMDP and between the NMDP and the other BBRC Projects (Toxicology and Infectious Diseases and Immunology). Positive outcomes of this new research strategy will be: 1) increased success in securing extramural funding; 2) a concurrent decrease in our dependence on RCMI funds; 3) the development and pursuit of multi-investigator and/or program project-type grant applications; and 4) a productive environment for training young scientists from underrepresented groups. Through this research plan, we will achieve our mission to contribute substantially to the health and education of people in the El Paso/Ciudad Juarez community as well as the missions of the NIH and NCRR.