Neuromedical Core

神经医学核心（NMC）的总体目标是提供全面的临床和 实验室评估、科学咨询、指导、培训和社区教育， 神经艾滋病在目前的资助期间，NMC促进了79个研究项目，包括观测 队列研究、临床病理学研究、影像学研究、临床试验和国际研究 由加州大学圣地亚哥分校和许多其他机构的合作研究人员进行。HNRC的合作 研究人员发现由NMC生成的数据，包括神经学诊断制剂，抗逆转录病毒药物， (ARV)治疗信息、HIV疾病分期信息、病毒载量和各种其他临床信息 实验室测量，是他们的数据分析和出版物必不可少的。 认识到保持活力和科学相关性需要不断适应 不断变化的需求HNRC研究企业和科学议程的许多主要 研究人员和合作者，我们建议以两种方式加强NMC的更新。一是 增加药理学部分，重点关注抗逆转录病毒药物渗透到CMS中。二是 整合了以前由细胞免疫学和液体核心执行的功能。新组织的 NMC由三个协作单元组成，每个协作单元包括公共资源（设备， 供应）和工作人员进行日常互动：临床单位;患者来源的样本单位;和 药理学和生物标志物单位。核心将有助于回答的科学问题的例子有 1)共同病原体和合并症如丙型肝炎病毒在神经艾滋病中的作用是什么 (HCV)和药物滥用2)脑脊液（CSF）是否提供了一个有用的窗口来评估 病毒-宿主相互作用和神经艾滋病的分子发病机制？3)中枢神经系统在病毒性 进化、适应和抗逆转录病毒药物耐药性的发生？4)宿主遗传学如何影响艾滋病毒 神经发病机制？ 通过协助调查人员在项目开发的各个层面上广泛不同的学科， 概念化的假设，研究执行，分析，解释和传播， NMC鼓励应用多种科学观点，并促进跨学科 合作与协调。我们将与神经成像，神经行为， 神经病毒学和神经生物学核心，以进一步刺激跨学科的目标。除了支持 研究的表现，NMC还提高和扩大了有效性和公众 与心理健康和艾滋病毒/艾滋病有关的新发现对健康的影响。

The over-arching objectives of the Neuromedical Core (NMC) are to provide comprehensive clinical and laboratory evaluations, scientific consultation, and mentorship, training, and community education in NeuroAIDS. In the current funding period the NMC facilitated 79 research projects including observational cohort studies, clinical-pathological investigations, imaging studies, clinical trials and international research performed by collaborating investigators at UCSD and many other institutions. The HNRC's collaborating investigators find data generated by the NMC, including neurological diagnostic formulations, antiretroviral (ARV) treatment information, HIV disease staging information, viral loads and a variety of other clinical laboratory measurements, to be essential for their data analyses and publications. Recognizing that maintaining vitality and scientific relevance necessitates continual adaptation to the changing needs of the HNRC research enterprise and the scientific agendas of its many principal investigators and collaborators, we propose to enhance the NMC in this renewal in two ways. First, we will add a pharmacology component that will focus on ARV drug penetration into the CMS. Second, we will incorporate functions previously carried out by the Cellular Immunology and Fluids Core. The newly-organized NMC is made up of three cooperative units, each comprising common resources (equipment, supplies) and staff that interact on a daily basis: a Clinical Unit; a Patient-Derived Sample Unit; and a Pharmacology & Biomarker Unit. Examples of scientific questions the Core will facilitate answering are 1) What is the contributory role in neuroAIDS of co-pathogens and comorbidities such as hepatitis C virus (HCV) and substance abuse? 2) Does cerebrospinal fluid (CSF) provide a useful window to evaluate virus-host interactions and molecular pathogenesis in neuroAIDS? 3) What is the role of the CNS in viral evolution, adaptation and the occurrence of ARV drug resistance? 4) How do host genetics influence HIV neuropathogenesis? By assisting investigators in widely diverging disciplines at all levels of project development, from conceptualization of hypotheses to study implementation, analysis, interpretation and dissemination, the NMC encourages the application of multiple scientific perspectives and stimulates interdisciplinary collaboration and coordination. We will collaborate closely with the Neuroimaging, Neurobehavioral, Neurovirology and Neurobiology Cores to further stimulate transdisciplinary aims. In addition to supporting the performance of research research, the NMC also enhances and extends the effectiveness and public health impact of new findings related to mental health and HIV/AIDS.