IMAGING CORE

斯克里普斯神经艾滋病临床前研究中心（SNAPS）的新表型组学核心将提供 SNAPS调查人员和其他人拥有尖端的分析支持和数据访问，以解决 代谢物和蛋白质分析以及功能基因组学方面的主要挑战。鉴定，定量， 以及广泛的代谢物和蛋白质与生物化学和转录事件的相关性 与神经艾滋病和中枢神经系统有关。迎接这一挑战是理解 疾病的进展以及诊断和治疗工具的发展。应用最新科学技术 高密度基因表达阵列、全球代谢物谱分析和比较 蛋白质组学分析将允许鉴定与以下相关的特定代谢物和蛋白质： 神经退行性过程，促进对neuroAIDS基本问题的更深入理解。 将提供Affyscore基因芯片表达阵列和自定义阵列技术， 不可用或昂贵得令人望而却步。Phenomics核心支持的一个关键组成部分将是 通过与拟议的系统积极合作，扩大生物信息学和统计学资源 生物和综合网络核心和行政核心的统计部分。这一协作 这些努力将导致数据收集、共享和分析能力同时多样化， 整合，为神经艾滋病研究创造了独特的资源。核心将继续提供培训 并协助生物信息学工具进行微阵列数据分析，蛋白质配体相互作用， 代谢组学和蛋白质组学，以及数据集的管理和传播。的最终目标 Prvenomics核心是提供分析支持的设计和实施的尖端 转录组学、代谢组学和蛋白质组学集中于HIV/AIDS的病理神经学效应。

The new Phenomics Core of the Scripps NeuroAIDS Preclinical Studies (SNAPS) Center will provide SNAPS investigators and others with cutting-edge analytical support and data access, to address the primary challenges in metabolite and protein profiling, and functional genomics. Identification, quantification, and correlation of the broad range of metabolites and proteins with biochemical and transcriptional events relevant to neuroAIDS and the central nervous system. Meeting this challenge is integral to understanding the progression of disease and the development of diagnostic and treatment tools. Applying state-of-thescience approaches in high density gene expression arrays, global metabolite profiling and comparative proteomic analysis will permit the identification of specific metabolites and proteins associated with neurodegenerative processes and facilitate a deeper understanding of basic problems in neuroAIDS. Affymetrix GeneChip expression arrays and custom array technology will be provided that would otherwise be unavailable or prohibitively expensive. A key component of the Phenomics Core support will be the expansion of bioinformatics and statistics resources through active collaboration with the proposed Systems Biology and Integrative Network Core and the Statistics section of the Administrative Core. This collaborative effort will result in data collection, sharing and analysis capabilities that are simultaneously diverse and integrated, generating a unique resource for neuroAIDS research. The Core will continue providing training and assistance with bioinformatics tools for microarray data analysis, protein-ligand interactions, metabolomics and proteomics, and the management and dissemination of datasets. The ultimate goal of the Prvenomics Core is to provide analytical support in the design and implementation of cutting edge transcriptomics, metabolomics and proteomics focused upon the pathoneurological effects of HIV/AIDS.