Genetic Epidemiology and Biostatistics Core

遗传流行病学和生物统计学核心结合了韦克基因分析方面的专业知识 森林大学医学院和阿拉巴马大学伯明翰分校。核心将继续 指导临床和遗传学数据收集的实验设计。酷睿将继续提供 数据管理、统计和遗传数据分析方面的专业知识。遗传流行病学的目标 和生物统计核心是(1)提供针对特定问题量身定做的适当实验设计 遗传和流行病学假说，(2)促进有效的数据收集程序，以准备 数据分析，(3)使用连锁不平衡和关联方法精炼易感区域，以及 (4)利用并在某些情况下开发分析系统性红斑狼疮表型的新方法。 遗传流行病学和生物统计学核心的长期目标是利用遗传和 收集系统性红斑狼疮患者及其家人的流行病学数据，以确定遗传和 导致SLE易感性的流行病学危险因素。一个详细的计划，以确保核心 成功地实现了它的目标。

The Genetic Epidemiology and Biostatistics Core combines the expertise in genetic analysis of Wake Forest University School of Medicine and the University of Alabama at Birmingham. The Core will continue to guide the experimental design for collection of clinical and genetic data. The Core will continue to offer expertise in data management, statistical and genetic data analysis. The goals of the Genetic Epidemiology and Biostatistics Core are to (1) provide appropriate experimental designs tailored to address specific genetic and epidemiologic hypotheses, (2) facilitate efficient data collection procedures for preparation of data analysis, (3) refine regions of susceptibility using linkage disequilibrium and association methods, and (4) utilize and, in some cases, develop novel methods for analysis of SLE phenotypes. The long-term goals of the Genetic Epidemiology and Biostatistics Core are to utilize genetic and epidemiologic data collected on SLE patients and their family members in order to identify genetic and epidemiologic risk factors that contribute to the susceptibility for SLE. A detailed plan to assure that the Core is successful in meeting its objectives is described.