International Symposium on Proline Metabolism and Human Health

描述(由申请者提供)：举办关于脯氨酸代谢的会议的主要目标是涵盖与人类健康和疾病相关的各种主题，并扩大该领域的研究人员网络。在从细菌到哺乳动物的各种生物体中，脯氨酸具有多方面的生物学和生化作用。脯氨酸代谢在各种生物体中的独特作用包括渗透调节、蛋白质伴侣、氮和碳的利用、非生物/生物应激反应、氧化应激保护以及营养适应和生存。在人类中，脯氨酸代谢被认为对生物能量学、细胞氧化还原控制、细胞凋亡、癌症、精神分裂症和结缔组织发育具有重要影响。脯氨酸代谢基因的先天缺陷表现为神经功能障碍，如精神分裂症、癫痫发生率增加、结缔组织疾病、过早衰老和骨量减少。首届Pro会议于2004年在国家癌症研究所举行，第二次会议于2007年举行。由于前几次会议的热情，第三次关于脯氨酸代谢的研讨会正在组织中，该研讨会将涵盖NIH感兴趣的一系列主题。将讨论的主题包括：(A)癌症中的P53和Pro信号通路；(B)精神分裂症中Pro脱氢酶的风险和保护功能的多态；(C)Pro的神经毒性；(D)引起吡咯酸-5-羧酸还原酶突变的疾病和结缔组织疾病；(E)Pro代谢循环和氧化应激；(F)营养应激反应；(G)锥体、适应和生存；(H)Pro的运输和在发病中的利用；(I)Pro代谢酶的结构和功能；(J)有机磷神经毒剂的解毒；(K)脯氨酸代谢基因表达的调控机制；(L)底物在脯氨酸氧化途径中的通道。会议项目有来自不同科学学科的演讲者，这将为年轻科学家提供极好的培训体验。会议计划的活动将促进初级科学家和更成熟的科学家之间的互动。这次会议为国际脯氨酸代谢研究人员提供了唯一的机会，让他们齐聚一堂，讨论新的成果以及他们的研究对人类健康和疾病的影响。 与公共健康相关：氨基酸Pro在从细菌到人类的各种生物体中都有多方面的作用。对脯氨酸代谢的研究有助于我们了解癌症的预防机制、携带寄生虫(如布鲁氏锥虫、非洲昏睡病)和致病菌(如金黄色葡萄球菌)如何适应和生存、线粒体能量过程、结缔组织和皮肤疾病以及精神分裂症等神经精神功能障碍。这次关于脯氨酸代谢的会议将使来自世界各地的研究人员能够讨论他们的最新成果，发起合作，并为改善人类健康和抗击传染病制定新的战略。

DESCRIPTION (provided by applicant): The main goals of holding a meeting on proline metabolism is to cover a diverse breadth of topics related to human health and disease and to increase the network of researchers in the field. Proline has multifaceted biological and biochemical roles in a variety of organisms from bacteria to mammals. The unique roles of proline metabolism in various organisms include osmolyte protection, protein chaperoning, nitrogen and carbon utilization, abiotic/biotic stress response, oxidative stress protection, and nutrient adaptation and survival. In humans, proline metabolism is recognized as having an important impact on bioenergetics, cellular redox control, apoptosis, cancer, schizophrenia, and connective tissue development. Inborn errors in proline metabolic genes are manifested in neurological dysfunctions such as schizophrenia, increased incidence of seizures, connective tissue diseases, premature aging, and osteopenia. The inaugural proline meeting was held in 2004 at the National Cancer Institute and a second conference was held in 2007. Due to the enthusiasm from previous meetings, a third symposium on Proline Metabolism is being organized that will cover a wide array of topics that are of interest to NIH. The topics that will be discussed include: (a) p53 and proline signaling pathways in cancer; (b) risk and protective functional polymorphisms of proline dehydrogenase in schizophrenia; (c) proline neurotoxicity; (d) disease causing mutations in pyrroline-5-carboxylate reductase and connective tissue disorders; (e) proline metabolic cycling and oxidative stress; (f) nutrient stress response; (g) trypanosomes, adaptation and survival; (h) proline transport and utilization in pathogenesis; (i) structure and function of proline metabolic enzymes; (j) detoxification of organophosphorus nerve agents; (k) regulatory mechanisms of proline metabolic gene expression; and (l) substrate channeling in the proline oxidation pathway. The conference program has speakers from diverse scientific disciplines, which will provide an excellent training experience for younger scientists. The planned activities of the conference will facilitate interactions between junior and more established scientists. This conference provides the only opportunity for the international community of proline metabolism researchers to gather to discuss new results and the impact of their research on human health and disease. PUBLIC HEALTH RELEVANCE: The amino acid proline has multifaceted roles in organisms ranging from bacteria to humans. Research into proline metabolism is helping our understanding of cancer preventing mechanisms, how disease carrying parasites (e.g., Trypanosoma brucei, African sleeping sickness) and pathogenic bacteria (e.g., Staphylococcus aureus) adapt and survive, mitochondrial energetic processes, connective tissue and skin disorders, and neuropsychiatric dysfunctions such as schizophrenia. This conference on proline metabolism will enable researchers from around the world to discuss their latest results, initiate collaborations and develop new strategies for improving human health and combating infectious diseases.