Liver Growth, Injury and Metabolism: Basic and Applied Biology

申请者描述(申请人提供)：本申请寻求部分支持美国实验生物学学会联合会(FASE B)夏季“肝脏生长、损伤和代谢：基础和应用生物学”研究会议。在过去的20年里，这个会议每两年举行一次，现在被公认为世界上最重要的会议，涵盖了涉及肝脏的基础科学研究的方方面面。会议将于2010年8月15日至20日在科罗拉多州的斯诺马斯举行。会议的主要目标是：i)整合肝脏生物学不同领域提供的研究进展，以促进国内和国际规模的新的合作项目；ii)鼓励初级和早期研究人员、女性和少数群体科学家从事肝脏研究，以确保肝脏疾病和生物学的研究保持活力；iii)通过基础和临床研究人员的互动，加速将肝脏生物学的基本进展转化为新的临床治疗方法。这些目标将通过具体的方案战略来实现。该计划分为九个主要环节，包括42位受邀演讲者的演讲。此外，这些会议将容纳多个简短的“最新”演讲，这些演讲将被选为代表肝脏研究中最重要和最及时的研究进展。初级调查员、少数民族调查员和女性调查员将获得优先考虑。该项目还提供了两个一对一对话的海报会议，以及在整个逗留期间演讲者和与会者之间非正式但亲密的科学交流的几个额外机会。具体主题包括肝脏分化和器官发生、健康和疾病中肝胆基因表达的调节、肝脏生长和再生、健康和疾病中的肝脏代谢、肝损伤和肝纤维化、肝癌、肝干细胞及其对再生医学和发展的影响、肝细胞移植和肝组织工程，以及基础和转化性肝脏病理生物学的最新进展。因此，该计划融合了肝脏健康和疾病的基础和应用方面最相关和最及时的主题，以促进科学交流、传播、教育、合作和翻译。 公共卫生相关性：叙事FASEB夏季研究会议“肝脏生长、损伤和新陈代谢：基础和应用生物学”是肝脏生物学基础和翻译研究的主要国际会议。这次会议已经举行了20年，历史上有180-200名调查人员参加。会议过去的成功和卓越导致了一个由大约80名科学家组成的中心小组，他们定期出席。这些科学家中的许多人构成了美国基础肝脏研究的核心，并代表了该领域的思想领袖。这次会议还吸引了许多初级调查人员，他们有机会展示他们的研究并加强联系。其他参与者申请拓宽他们对肝脏生物学的理解或对特定的方案内容感兴趣。因此，这次会议在其内容上是独一无二的，在议题的及时性和国际公认的基础和翻译肝脏生物学的首要会议上处于领先地位。

DESCRIPTION (provided by applicant): The current application seeks partial support for the Federation of American Societies for Experimental Biology (FASEB) summer research conference on "Liver Growth, Injury and Metabolism: Basic and Applied Biology". For the past 20 years, this meeting has been held biennially and is now recognized as the world's premier conference covering all aspects of basic science research involving the liver. The conference will be held from August 15th to 20th, 2010 in Snowmass, Colorado. The main goals of the conference are to i) integrate the research advances offered by disparate areas of liver biology in order to foster new collaborative projects on both national and international scale, ii) encourage junior and early stage investigators, women and minority scientists to pursue liver research to ensure that the study of hepatic disease and biology remains vigorous and iii) accelerate translation of fundamental advances in liver biology into novel clinical treatments through the interactions of basic and clinical researchers. These goals will be achieved through specific programmatic strategies. The program is divided into nine major sessions and includes presentations from forty-two invited speakers. In addition, these sessions will accommodate multiple short 'late-breaking' talks that will be chosen to represent the most significant and timely research advances in liver research. Preference will be given to junior, minority and women investigators. The program also provides two poster sessions for one-on-one dialogue and several additional opportunities for informal, yet intimate scientific exchange among speakers and attendees throughout the stay. Specific session topics include liver differentiation and organogenesis, regulation of hepatobiliary gene expression in health and disease, liver growth and regeneration, liver metabolism in health and disease, liver injury and hepatic fibrosis, liver cancer, liver stem cells and implications in regenerative medicine and development, hepatocyte transplantation and hepatic tissue engineering and recent advances in basic and translational liver pathobiology. Thus, the program amalgamates the most relevant and timely topics in basic and applied aspects of liver health and disease to promote scientific exchange, dissemination, education and collaboration and translation. PUBLIC HEALTH RELEVANCE: Narrative The FASEB summer research conference on "Liver Growth, Injury and Metabolism: Basic and Applied Biology" is the premier international conference on basic and translational research in liver biology. The meeting has been held for the last 20 years and historically has been attended by 180 - 200 investigators. The past success and excellence of the meeting has resulted in a central group of approximately 80 scientists who attend regularly. Many of these scientists form the core of basic liver research in the U.S.A., and represent the thought-leaders in the field. The meeting also attracts many junior investigators, who are given the opportunity to present their research and enhances networking. Other participants apply to broaden their understanding of liver biology or are interested in specific programmatic content. Thus, the meeting is unique in its content, at the forefront in timeliness of topics and internationally recognized premier conference in basic and translational liver biology.