2010 Cold Spring Harbor Laboratory Symposium On Quantitative Biology: Nuclear Org

描述(申请人提供)：斯图尔特，大卫冷泉港实验室会议第75届定量生物学核组织和功能年度研讨会2010年6月2-7日冷泉港定量生物学研讨会于每年6月初在纽约冷泉港实验室举行。他们聚集了来自世界各地的大约300-400名科学家，介绍和评估快速发展的生物研究领域的新数据和新想法。每年，都会选择一个似乎处于需要全面和深入审查的阶段的主题。研讨会总是寻求吸引来自国外和美国的研究人员，以确保项目的广度和深度，并利用他们的具体贡献。他们还寻求为优秀的年轻科学家，包括研究生和博士后研究员，提供参与和与更多资深科学家交流的机会。研讨会还寻求女性和少数族裔科学家的参与。研讨会聚集了使用各种方法的科学家，例如遗传学、生物化学、分子生物学、细胞生物学和结构研究，以分析所讨论领域的问题。领先的Strand档案馆将讲座的录像立即提供给与会者的同事，而研讨会的会议记录则由实验室发布，从而向比出席会议的科学家更广泛的受众提供。在研讨会期间对主要科学家进行的深入访谈提供了当前研究状况的另一种快照。一年一度的研讨会将继续计划，以推动生物医学科学的进步。该提案要求在2010年期间为第75届冷泉港专题讨论会提供支助，该专题讨论会的重点将是“核组织和功能”，并反映了对核的描述性细胞生物学方法和对核过程的机制驱动方法之间的日益趋同，这一方法现在揭示了过程之间的联系和动态，以更好地确定细胞主要控制中心的结构和功能组织如何运作。特别是，这项申请寻求联邦支持初级参与者，包括选定的研讨会研究员，在这一历史性时刻积极介绍他们的最新工作，以及一些被邀请的演讲者，他们构成了会议的核心。 与公共健康相关：细胞核是细胞的运作总部，构成我们遗传物质的DNA和染色体就存放在这里。细胞核有一个明确的周边或膜，包括蛋白质、核酸和小分子在内的物质必须通过门状的小孔进出细胞核。越来越清楚的是，在细胞核内，一个复杂而动态的结构有助于确定基因何时以及如何打开和关闭。包括加速衰老在内的人类疾病现在被认为涉及其中一些结构或机制的异常。本次研讨会将讨论核的动态组织和功能，以及我们对这些系统的理解如何有助于预防或治疗这些疾病。

DESCRIPTION (provided by applicant): Stewart, David Cold Spring Harbor Laboratory Conference 75th Annual Symposium on Quantitative Biology Nuclear Organization and Function June 2 - 7, 2010 The Cold Spring Harbor Symposia on Quantitative Biology are held yearly at the beginning of June at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. They bring together approximately 300-400 scientists from all over the world to present and evaluate new data and ideas in rapidly moving areas of biological research. Each year, a topic is chosen that seems to be at a stage where general and intensive scrutiny and review is needed. The Symposia always seek to bring research workers from abroad, as well as the U.S., so as to ensure the wide scope and depth of the program and to take advantage of their specific contributions. They also seek to provide outstanding younger scientists, both graduate students and post-doctoral fellows, with an opportunity to participate and communicate with more senior scientists. The Symposia also seek to have participation from women and minority scientists. The Symposia bring together scientists who use a variety of approaches, e.g., genetics, biochemistry, molecular biology, cell biology, and structural studies, to analyze problems in the area under discussion. The Leading Strand archive makes video recordings of the talks immediately available to colleagues of those who attended, while the proceedings of the Symposia are published by the Laboratory and thus made available to a wider audience than the scientists who attend the meeting. In-depth interviews with leading scientists undertaken during the Symposium provide an alternative snapshot of the state of current research. The annual Symposia will continue to be planned to further the progress of advancements in biomedical science. This proposal request support for the period 2010 to cover the 75th Cold Spring Harbor Symposium which will focus on "Nuclear Organization and Function" and reflects the growing convergence between descriptive cell biological approaches to the nucleus and mechanism-driven approaches to nuclear processes that is now shedding light on the connections and dynamics between processes, to better establish how the structural and functional organization of the primary control center of the cell operates. In particular, this application seeks federal support for junior participants including selected Symposium Fellows to actively present their latest work at this historic occasion, as well as some of the invited speakers who form the core of the meeting. PUBLIC HEALTH RELEVANCE: The nucleus is the operational headquarters of the cell, where the DNA and chromosome that make up our genetic material are housed. The nucleus has a well defined periphery or membrane through which materials including proteins, nucleic acids and small molecules have to traffic into and out the nucleus through gate-like pores. It is becoming increasingly clear that inside the nucleus, a complicated and dynamic architecture helps to determines when and how genes are turned on and off. Human diseases including accelerated aging are now understood to involve aberrations in some of these structures or mechanisms. This Symposium will address the dynamic organization and function of the nucleus, and how advances in our understanding of these systems may help in preventing or treating these diseases.