Intellectual and Development Disabilities Research Center

描述(申请人提供)：这个IDDRC是由费城儿童医院(CHOP)和宾夕法尼亚大学(宾夕法尼亚大学)合作建立的。该续签申请要求支持六个核心单位和三个新方案开发(NPD)项目。核心是：(1)提供全面管理的行政核心(核心A)，包括(I)所有教育方案，(Ii)每月系列讲座，(Iii)新开发项目，以及(Iv)中大西洋研究联盟，这是一个新的企业，合并了宾夕法尼亚大学、约翰霍普金斯大学和儿童国家医学中心的IDDRCs的物质和智力资源；(2)生物统计和生物信息学核心(核心B)，为研究设计、统计分析和生物信息学/基因组学提供咨询；(3)分子遗传学核心(核心C)，为DNA测序、荧光片段分析、COSMIG重叠群突变检测、YAC文库筛选、定量聚合酶链式反应分析和基因作图等提供集中设施；(4)分析神经化学核心(核心D)，提供有关生化分析的专业知识和支持，包括(I)研究活细胞中的第二信使系统；(Ii)测量脑组织中的生物胺和氨基酸；(Iii)稳定同位素的质谱分析，用于研究整个大脑和体外系统中代谢物周转的动力学；(5)细胞神经科学核心(核心E)，提供关于(I)细胞结构分析、(Ii)细胞培养和(Iii)使用电压敏感染料的切片制备中的电路功能的光学成像方面的支持和建议；(6)新的神经成像核心(核心F)，支持人类和动物模型的各种体内神经成像方法，包括(I)磁共振成像、(Ii)PET和(Iii)脑磁图。自2004年更新以来，调查人员根据我们用户的反馈对每个核心进行了修改。IDDRC每年为100多个NIH资助的项目提供服务，总价值为1200万美元(NICHD为150万美元)。该中心包括宾夕法尼亚大学医学院、兽医学院、护理学院、维斯塔尔研究所和艺术与科学学院15个系的70多名教职员工。

DESCRIPTION (Provided by Applicant): This IDDRC is a collaboration of the Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania (Penn). This renewal application requests support for six core units and three new program development (NPD) projects. The cores are: (1) An Administrative Core (Core A) that provides overall management, including (i) all educational programs, (ii) monthly lecture series, (iii) the NPD projects, and (iv) the Mid-Atlantic Research Consortium, a novel venture that merges physical and intellectual resources of the IDDRCs at Penn, Johns Hopkins University, and Children's National Medical Center; (2) A Biostatistics and Bioinformatics Core (Core B) that provides consultation for study design, statistical analysis, and bioinformatics/genomics; (3) A Molecular Genetics Core (Core C) that provides a centralized facility for DNA sequencing, fluorescent fragment analysis, mutation detection with cosmig contigs, screen of YAC libraries, quantitative PCR analysis, and gene mapping, etc.; (4) An Analytical Neurochemistry Core (Core D) that provides expertise and support with regard to biochemical analyses, including (i) the study of second messenger systems in living cells; (ii) measurements of biogenic amines and amino acids in brain tissues; (iii) mass spectrometry assays of stable isotopes for kinetic studies of metabolite turnover in both whole brain and in vitro systems; (iv) a Proteomics Sub-core that identifies proteins and peptides as well as salient post-translational modifications such as phosphorylation; (5) A Cellular Neuroscience Core (Core E) that provides support and advice with regard to (i) cytoarchitectural analysis, (ii) cell culture, and (iii) optical imaging of circuit function in slice preparations using voltage sensitive dyes; (6) A new Neuroimaging Core (Core F) that supports a variety of in vivo neuroimaging methods in humans and animal models, including (i) MRI, (ii) PET, and (iii) MEG. The investigators have modified each core in response to feedback from our users since the 2004 renewal. The IDDRC services more than 100 NIH-funded projects with an aggregate value of >$12 million per year (> $1.5 million from NICHD). The Center includes an excess of 70 Penn faculty at 15 departments at the Schools of Medicine, Veterinary Medicine, Nursing, the Wistar Institute, and the College of Arts and Sciences.