Scientific and Administrative Core: Dartmouth Medical School

该核心提供影响整个中心的科学和行政支持。它提供了 科学的管理和财务管理是中心有效和负责任地运作所必需的。这个核心将支持组织方面，使研究能够以综合和协同的方式进行，良好的沟通，包括获得和利用与单个项目和整个中心有关的建议的渠道。它还提供了一些关键的过度投入和支持，直接推动科学发展，并导致能力建设，这是中心的总体目标。后者包括：1）先进的生物统计支持和2）指导工具的开发，使其联合收割机全面的业务技术能力和在可能使用的环境中有效运作的能力。预算的制定是为了促进这一核心的能力，履行其对整个项目的责任：开发优化的关键组件，以推进技术， 所有三个项目，然后开发一个原型，将这些发展纳入所有三个项目的实地部署仪器。该核心中的人员具有跨所有三个项目的特定职责，并且还整合来自其他核心的概念、软件和硬件。他们也有具体的责任与我每个项目。正如实验研究计划中所指出的，该核心的人员将参与三个项目的日常运作，特别是开发专用仪器，以促进每个项目。因为这三个项目的时间承诺会随着时间的推移而变化，并且在这个核心中的个人之间，最有效的方法是不要试图指出他们在这三个项目上的工作比例。相反，我们将有能力和灵活性，提供在所有三个项目中取得最大进展所需的努力，并将能够 更快地推进能够最快实现外地部署的项目。作为一个粗略 据估计，项目1和项目3（位于达特茅斯）的直接项目支持活动约占40%，项目2（位于佛罗里达州）的直接项目支持活动约占20%，尽管在项目2的主要负责人的直接指导下，项目2的大量工作计划也将在达特茅斯进行。在赠款期间，该核心的人员将花费越来越多的时间和精力在设计、建造和测试将要生产的原型仪器上。项目人员将密切参与设计和测试阶段。

This core provides scientific and administrative support that impacts the entire Center. It provides the scientific management and financial management essential for the effective and responsible operation of the Center. This core will support the organizational aspects that enable the research to be carried out in an integrated and synergistic manner, with excellent communication including channels for obtaining and utilizing advice that pertains both to individual projects and the center as a whole. It also provides some key over-arching input and support that directly advance the scientific developments and lead to the construction ofthe capabilities that are the overall goal ofthe Center. The latter include: 1) sophisticated biostatistical support and 2) guidance of the development of the instruments so that they combine both fully operational technical capabilities and the ability to operate effectively in the environment in which they are likely to be utilized. The budget has been developed to facilitate the capabilities of this core carrying out its responsibilities forthe overall project: to develop optimized critical components to advance the technology in all three projects and then to develop a prototype that incorporates the developments into field deployable instruments for all three projects. The personnel in this core have specific responsibilities that extend across all three projects and also incorporate concepts, software, and hardware from the other cores. They also have specific responsibilities with I each project. As noted within the experimental research plans the personnel in this core will be involved in the day to day operations of the three projects, especially in the development ofthe specialized instrumentation to facilitate each project. Because the time commitments among the three projects will vary over time and among individuals in this core, it is most efficient to not to try to indicate a set proportion of their efforts for the three projects. Instead we will have the capability and the flexibility to provide the effort that is need to attain maximal progress in all three projects and will be able to advance more quickly projects where the field deployability can be achieved most rapidly. As a rough estimate, the direct project-supporting activities will be roughly 40% each for Projects 1 and 3 (these are at Dartmouth) and 20% for Project 2 which is centered at Florida although there also will be a significant amount of the work plan for Project 2 carried out at Dartmouth under the direct guidance of the PI of project 2. During the course of the grant period the personnel in this core will be spending an increasing amount of their time and effort in the design, construction, and testing ofthe prototype instruments to be produced. The personnel of the projects will be closely involved in both the design and the testing phases.