2011 Cell Biology of Metals Gordon Research Conference

描述（由申请人提供）：戈登金属细胞生物学会议提供了一个高度互动的论坛，让初级和高级研究人员都能了解我们对细胞内、细胞间和生物体内金属稳态的理解的最新进展。金属离子，如锌、铜、铁和锰，既是生命所必需的，也是高浓度有害的，现在与许多疾病有关，从发育障碍到神经、造血和免疫系统功能障碍。金属稳态失调、金属利用和辅助因子组装与人类疾病之间的联系，以及金属可利用性的变化如何影响对细菌病原体的先天免疫，这些只是2011年金属细胞生物学戈登会议众多主题中的两个。我们的具体目标是(1)组织和支持一个会议，让参与者了解我们对过渡金属稳态的细胞生物学的理解的最新进展，从模式生物到人类；(2)促进科学思想的有效交流，作为发展不同研究人员之间合作的一种手段，否则可能无法相互作用，从生物无机化学家到质谱学家到结构和细胞生物学家，跨越多种具有生物学意义的金属离子；(3)创建一个高度互动的论坛，允许初级研究人员，从研究生到博士后科学家到助理教授，与我们快速发展的领域的知名领导者交流思想。来自代表性不足群体的女性和科学家在我们的会议计划中占据突出地位。其他科学会议将涵盖金属离子传感的分子和结构生物学、运输、运输和外排、金属与氧化应激传感的相互作用、下一代金属总量和生物可利用性量化技术，以及全基因组金属组学和离子组学揭示的植物金属分配。邀请该领域的新老领导人以及选定的海报摘要作口头报告。

DESCRIPTION (provided by applicant): The Cell Biology of Metals Gordon Conference provides a highly interactive forum that allows junior and senior investigators alike to learn of recent advances in our understanding of metal homeostasis in cells, between cells and within organisms. Metal ions such as zinc, copper, iron and manganese are both essential for life and deleterious at high concentrations and are now linked to numerous diseases ranging from developmental disorders and dysfunction of the nervous, hemopoietic and immune systems. The connections between misregulation of metal homeostasis, metal utilization and cofactor assembly and human disease, and how changes in metal availability influence innate immunity against bacterial pathogens represent just two of the many topical themes of the 2011 Cell Biology of Metals Gordon Conference. Our specific aims are (1) To organize and support a conference that allows participants to learn of recent advances in our understanding of the cell biology of transition metal homeostasis, from model organisms to humans; (2) To promote the efficient exchange of scientific ideas as a means to develop collaborations among diverse investigators that otherwise may not interact, from bioinorganic chemists, to mass spectrometrists to structural and cell biologists, that cuts across multiple metal ions of biological significance; and (3) To create a highly interactive forum that allows junior investigators, from graduate students to postdoctoral scientists to assistant professors, to exchange ideas with established leaders in our rapidly growing field. Women and scientists from underrepresented groups figure prominently in our conference program. Other scientific sessions will cover the molecular and structural biology of metal ion sensing, trafficking, transport, and efflux, the interplay of metals and oxidative stress sensing, next generation technologies to quantify total and bioavailable metals, and metal allocation in plants as revealed by genome-wide metallomics and ionomics. Invited oral presentations will be given by both new and established leaders in the field, as well as from selected poster abstracts. PUBLIC HEALTH RELEVANCE: The 2011 Cell Biology of Metals Gordon Research Conference will present recent advances in our understanding of transition metal (iron, copper, zinc, manganese and cobalt) homeostasis in cells, between cells and within organisms. Iron metabolism is humans and discussion of how bacterial pathogens function to exploit the metal ion landscape to enhance survival in the human host are two important topics to be covered. In addition, this conference will highlight discussions of how misregulation of metal homeostasis and utilization underscores human disease.