Overcoming breast cancer heterogeneity and resistance using a novel therapeutic approach targeting the metastasis suppressor NDRG1.

乳腺癌（BrCa）是女性癌症死亡的主要原因，目前的治疗方法会产生耐药性，导致转移性进展。我将评估一种新的BrCa治疗策略，靶向一种能够抑制BrCa多个关键驱动因素的基因，使用一种新的强效和选择性抗癌剂。这种方法有可能克服对当前治疗的耐药性，减轻转移的发生，改善BrCa患者的预后。

Breast cancer (BrCa) is the leading cause of cancer death in women and current treatments suffer from development of resistance, leading to metastatic progression. I will assess a novel treatment strategy for BrCa, targeting a gene that is able to inhibit multiple key drivers of BrCa, using a novel potent and selective anti-cancer agent. This approach has the potential to overcome resistance to current therapies and alleviate the onset of metastasis, to improve prognosis for BrCa patients.