PREDICTION OF CHEMOTHERAPY INDUCED CARDIOMYOPATHY WITH MRI DETECT I

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多柔比星可延长许多儿童和成人癌症患者的生存期并减轻肿瘤负担，但其使用可导致不可逆的充血性心力衰竭（CHF）。赫赛汀、紫杉醇和环磷酰胺也是广泛用于治疗癌症并与心脏毒性相关的药物。 虽然在化疗过程中检测到的左心室射血分数（LVEF）下降可以预测CHF的发生，但它可能仅发生在不可逆的心脏损伤持续之后。 最近，心血管磁共振成像（MRI）已被用于量化 左心室舒张期局部舒张的区域性变化。 儿童研究 在接受阿霉素治疗的患者中， 会导致左心室射血分数下降 从我们的 研究机构指出，MRI可用于检测左心室舒张功能异常， 不同程度LVEF的患者。 我们的目的是确定接受化疗的癌症患者的心脏毒性与左心室舒张期舒张或心肌灌注减少之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Doxorubicin prolongs survival and reduces tumor burden for many children and adults with cancer, but its use can cause irreversible congestive heart failure (CHF). Herceptin, Paclitaxel and Cyclophosphamide are also agents that are widely used for treatment of cancer and are associated with cardiotoxicity. Although a fall in left ventricular ejection (LVEF) detected during the course of chemotherapy may forecast the onset of CHF, it may occur only after irreversible cardiac damage has been sustained. Recently, cardiovascular magnetic resonance imaging (MRI) has been used to quantify regional changes in left ventricular diastolic regional relaxation. Studies in children have documented alterations in LV diastolic function in patients receiving Doxorubicin therapy often precede a deterioration in left ventricular ejection fraction. Pilot data generated from our institution indicates that MRI can be used to detect abnormalities of left ventricular relaxation in patients with varying degrees of LVEF. It is our intent to identify the association between cardiotoxicity and reductions in left ventricular diastolic relaxation or myocardial perfusion measured with MRI in cancer patients receiving chemotherapy.