Photoacoustic CT for Preclinical Molecular Imaging

描述(申请人提供)：该合作研究项目的长期目标是将用于进行临床前分子成像的光声计算机断层扫描(PCT)扫描仪原型商业化。这种扫描仪是由光电公司开发的，资金来自国家癌症研究所(R44-CA-102891)的快速通道SBIR拨款和我们Endra，Inc.的额外私人资金。印第安纳大学、普渡大学和光电公司的研究人员在许多小鼠癌症模型中评估了这种设备，并开发了定量技术来测量三维空间分辨率的血红蛋白浓度、氧饱和度和外源分子探针在组织中的累积。这项桥梁拨款将补充Endra的额外资金，用于持续的产品开发，包括仪器和软件功能，将在癌症动物模型中得到验证。

DESCRIPTION (provided by applicant): The long-term objective of this collaborative research project is to commercialize a prototype photoacoustic computed-tomography (PCT) scanner for conducting preclinical molecular imaging. This scanner has been developed by OptoSonics with funding from a Fast Track SBIR grant from the National Cancer Institute (R44-CA-102891) and additional private funding from our Endra, Inc. Researchers at Indiana University, Purdue University and OptoSonics evaluated this device in a number of murine models of cancer and developed quantitative techniques to measure hemoglobin concentration, oxygen saturation and accumulation of exogenous molecular probes in tissue in three dimensions with spatial resolution < 350 ¿m. This Bridge grant will supplement additional financing from Endra for continued product development, including instrumentation and software features to be validated in animal models of cancer.