Enhanced Surveillance for New Vaccine Preventable Disease

描述(由应用程序提供)：德克萨斯儿童医院旨在建立和运营一个全年监测地点，作为更大的全国新疫苗监测网络(NVSN)的一部分，以更好地了解疫苗可预防疾病的负担、新疫苗的影响以及疫苗政策变化的影响。为了了解轮状病毒或其他疫苗可预防疾病的疾病负担，德克萨斯儿童医院的监测小组建议在所有赠款年度将有急性胃肠炎症状的儿童纳入急诊和住院环境。由于德克萨斯儿童医院的急诊科每年治疗8.2万名来自多个县地区的儿童，这些儿童在人口结构上与大休斯顿地区的儿童相似，该医院非常适合进行此类监测活动。粪便样本将在入学时或由专人从所有入学儿童身上收集。所有粪便样本将用旋转克隆酶免疫测定法进行检测。粪便样本轮状病毒抗原检测呈阳性的儿童，病例患者，然后将与提交给德克萨斯州儿童儿科协会的健康患者进行比较，以获得良好的儿童护理，对照患者。完整的疫苗接种历史将从病例和对照患者那里收集。将确定轮状病毒的疫苗效力，可能还有其他疫苗可预防的疾病。此外，将从病例和健康儿童的子集收集唾液样本，以评估FUT2分泌物抗原状态。在资助年度2至5年内，我们建议与疾病控制与预防中心合作，协助发展和推行更多计划。这些项目可能包括但不限于：将监测活动扩展到其他疫苗可预防的疾病，评估新疫苗的使用情况及其对提供者政策和实践习惯的影响，在采用新疫苗后对一群儿童进行纵向研究，涉及开发新研究方法的实验室研究，以及与疫苗政策有关的保健费用研究。 公共卫生相关性：得克萨斯州儿童医院(TCH)欢迎有机会响应RFA-IP-11010的资助机会，该机会将建立一个监测和评估点网络，以最终评估新疫苗和疫苗政策的影响。由于德克萨斯儿童医院的使命是改善我们社区的健康，我们有兴趣了解疫苗可预防疾病的负担，并参与一个将评估疫苗在我们社区的影响的全国网络。

DESCRIPTION (provided by application): Texas Children's Hospital aims to establish and operate a year round surveillance site as part of a larger national New Vaccine Surveillance Network (NVSN) to better understand the burden of vaccine-preventable disease, the impact of new vaccine and the impact of changing vaccine policies. To understand the disease burden of rotavirus or other vaccine-preventable diseases, the surveillance team at Texas Children's Hospital proposes to enroll children with symptoms of acute gastroenteritis in both emergency and inpatient settings during all grant years. As the Texas Children's Hospital emergency department treats >82,000 children per year from a multi-county area who are demographically similar to the children in the greater Houston area, the hospital is well suited to conduct such surveillance activities. Fecal specimens will be collected from all enrolled children at the time of enrollment or by courier. All fecal specimens will be tested using Rotaclone enzyme immunoassay. Children whose fecal specimens test positive for rotavirus antigen, case patients, will then be compared with healthy patients who present to the Texas Children's Pediatric Associates for well-child care, control patients. Complete vaccination histories will be collected from case and control patients. Vaccine effectiveness for rotavirus, and possibly other vaccine-preventable diseases, will be determined. Additionally, saliva specimens will be collected from a subset of case and healthy children for assessment of FUT2 secretor antigen status. During grant years 2-5, we propose to collaborate with the CDC to assist in the development and implementation of additional projects. These projects may include, but would not be limited to the following: extension of surveillance activities to other vaccine-preventable diseases, evaluation of uptake and impact of new vaccines on provider policies and practice habits, longitudinal studies involving a cohort of children following new vaccine introduction, laboratory studies involving the development of new research methods, and health care costs studies associated with vaccine policy. PUBLIC HEALTH RELEVANCE: Texas Children's Hospital (TCH) welcomes the opportunity to respond to funding opportunity RFA-IP-11010 that will establish a network of surveillance and evaluation sites to ultimately assess the impact of new vaccines and vaccine policies. As the mission of Texas Children's Hospital is to improve the health of our community, we are interested in understanding the burden of vaccine-preventable diseases and participating in a national network that will evaluate the impact of vaccines in our community.