Molecular Medicine Training Program

描述（由申请人提供）：凯斯西储大学医学院的分子医学培训计划是专门为培养博士前学生采取科学进步从“板凳到床边”。它利用四个因素来创造特别适合这一目的的环境。首先，该计划位于Lerner研究所，克利夫兰诊所和医学院的医生和科学家历来密切合作，专注于人类疾病的原因和治疗的前沿研究。第二，整个第一年设计了一个新的核心课程，为在人体器官系统和疾病的背景下提出的基本科学原理提供坚实的基础。研究报告和轮换，研讨会期刊俱乐部，和学生务虚会加强了整个培训的基本科学原理的转化应用。第三，培训计划包含广泛的培训师领导优秀的翻译研究实验室，我们的学员进行轮换和论文工作。这些实验室的范围和实力，他们的合作互动，以及培训人员的承诺，以支持培训计划是在培训计划的合议科学环境的证据。最后，为了确保每个学员都了解其研究领域的临床方面，每个人都会选择一名临床导师，帮助组织个人临床经验。通过这种经验，学员被介绍给病人的诊断和治疗的第一手资料。为了进一步强调与临床实践的联系，培训计划的学生与勒纳医学院的医学生一起参加联合课程。经验表明，这些正在接受培训成为医生科学家的医科学生，以及正在临床应用于基本科学观察的我们的学员，彼此有很多东西要学习。该提案寻求为培训方案内的7名受训人员提供资金。随着第四期培训班的招收，很明显，培训方案已得到全国的承认，并吸引了越来越多的申请人，目前有27名符合培训补助金条件的受训人员与该方案有关。学员们正热切地准备成为下一代NIH资助实验室的领导者，将基本的科学原理转化为满足患者需求的方法。事实上，该计划是专门为解决在最近的NIH路线图中确定的转化研究的需求而设计的，这解释了它的年轻，并强调了促进其成长和成熟的重要性。 公共卫生相关性：现代科学的一个主要目标是将实验室发现转化为人类疾病的改进诊断和治疗。分子医学培训计划旨在培养年轻的科学家，通过专门设计的课程，优秀实验室的培训以及与执业临床医生的直接互动来完成这一任务。

DESCRIPTION (provided by applicant): The Molecular Medicine Training Program of the Case Western Reserve University School of Medicine is specifically designed to train pre-doctoral students to take scientific advances from "bench to bedside". It takes advantage of four factors to create an environment particularly suited to this purpose. First, this Program is located in the Lerner Research Institute where physicians and scientists from both the Cleveland Clinic and the School of Medicine have historically worked closely together to focus cutting edge research upon the causes and treatments of human illness. Second, a novel core curriculum has been designed throughout the first year to provide a solid foundation in basic scientific principles presented in the context of human organ systems and disease. Research presentations and rotations, seminars journal clubs, and a student retreat reinforce the translational application of the basic scientific principles throughout training. Third, the Training Program contains a broad range of trainers heading outstanding translational research laboratories in which our trainees perform rotations and thesis work. The range and strength of these laboratories, their collaborative interactions, and the commitment of the trainers to support of the Training Program is evidence of the collegial scientific environment within the Training Program. Finally, to ensure that each of the trainees comes to understand the clinical aspects of their area of investigation, each selects a Clinical Mentor who helps organize an individual clinical experience. Through this experience trainees are introduced to patient diagnosis and treatment on a first hand basis. To further emphasize the connection to clinical practice, students in the Training Program take a joint course with medical students of the Lerner College of Medicine. Experience has shown that these medical students who are in training to be physician scientists, and our trainees who are finding clinical application to basic scientific observations, have much to learn from one another. This proposal seeks funding for 7 trainees within the Training Program. With admission of its fourth class, it has become clear that the Training Program has gained national recognition and attracted an ever increasing number of applicants, with 27 training grant eligible trainees currently associated with the Program. The trainees are eagerly preparing to take their places as the leaders of the next generations of NIH funded laboratories translating basic scientific principles to address patient needs. The fact that this Program was specifically designed to address the needs for translational research identified in the recent NIH roadmap explains its youth, and emphasizes the importance of promoting its growth and maturation. PUBLIC HEALTH RELEVANCE: A major goal of modern science is to translate laboratory findings into improved diagnosis and treatment of human diseases. The Training Program in Molecular Medicine is designed to train young scientists to accomplish this task with a specifically designed curriculum, training in outstanding laboratories, and direct interactions with practicing clinicians.