Translational Research Training in Cancer Etiology and Prevention

描述（申请人提供）：鉴于有能力进行全面研究，将基本知识从实验室转化为临床和社区环境，以改善癌症预防和控制的研究科学家严重短缺，该研究培训计划的目的是提供综合培训，匹兹堡大学癌症研究所的学科研究和教学环境。受训者将接受培训，了解环境暴露和遗传及其他生理因素在人类癌症发展和进展中的作用。该培训计划涉及临床试验研究，转化研究和基于人群的癌症观察和干预研究中不同轨道的跨学科培训课程。学员将与多学科团队中经验丰富的导师合作，进行从人群中的机械实验和观察性研究到随机干预研究的研究，以测试化疗和免疫预防剂对人类癌症保护的功效。指导研究将在研究设计、方法开发、研究方案的实施、数据收集、分析和解释以及手稿编写和出版方面为学员提供直接的研究经验。学员还将学习如何将临床前实验和/或观察性研究的发现转化为癌症预防的随机干预研究。这项计划的独特训练将培养下一代科学家 他可以领导癌症病因学和预防方面的前沿转化研究。 该培训计划是19名导师的共同努力，他们正在进行积极的研究项目， 匹兹堡大学癌症研究所（UPCI）的独立研究基金。这些院系来自以下研究项目，包括癌症流行病学，预防和控制;肿瘤学中的生物行为医学;癌症免疫学;癌症生物信息学;分子治疗和药物发现。UPCI是一家排名第一的综合性癌症中心，2013年直接研究资金为9200万美元，将为学员提供尖端的转化研究培训。 我们建议这个研究培训计划将支持两名博士后研究员在第1年和4名博士后学员在每年的2-5。根据最近参与计划的申请人数据，鉴于参与导师的研究和培训以及拟议的多学科培训的卓越性，我们预计将有一个相对较大的候选人库来申请这个培训计划。 培训计划的进展和成功将每年由一个指导NCI资助的培训计划的专家小组进行评估。在培训后的10年里，将密切跟踪和跟踪受训人员的职业发展和研究活动。

DESCRIPTION (provided by applicant): Given the severe shortfall of research scientists who are capable of conducting comprehensive studies that can translate fundamental knowledge from the bench to the clinical and the community settings for the improvement of cancer prevention and control, the purpose of this research training program is to provide integrated training in an inter-disciplinary research and teaching setting at the University of Pittsburgh Cancer Institute. Trainees will be trained in understanding the role of environmental exposures and genetic and other physiological factors in the development and progression of cancer in humans. The training program involves cross-disciplinary training courses in different tracks in the Clinical Trial Research, the Translational Research, and the Population-Based Observational and Interventional Research on cancer. Trainees will work with experienced mentors in a multiple disciplinary team conducting researches from mechanistic experiments and observational studies in populations to randomized intervention studies to test the efficacy of chemo- and immuno-preventive agents on cancer protection in humans. The mentored research will provide direct research experience to trainees in study design, methodological development, implementation of research protocol, data collection, analysis and interpretation, and manuscript preparation and publication. Trainees also will learn how to translate discoveries from pre-clinical experimental and/or observational studies into randomized intervention studies for cancer prevention. The unique training of this program will train next generation of scientists who can lead the cutting-edge translational research on cancer etiology and prevention. This training program is a joint effort of 19 preceptors who are conducting active research projects all with independent research funding in University of Pittsburgh Cancer Institute (UPCI). These faculties are from the following research programs including Cancer Epidemiology, Prevention and Control; Biobehavioral Medicine in Oncology; Cancer Immunology; Cancer Bioinformatics; and Molecular Therapeutics and Drug Discovery. UPCI, a top-ranked Comprehensive Cancer Center with $92 million direct research funding in 2013, will provide trainees with cutting-edge translational research training. We propose this research training program will support two post-doctoral fellows in year 1 and 4 post-doctoral trainees in each of years 2-5. According to recent data on applicants to participating programs, we expect to have a relatively large pool of candidates who will apply to this training program given the excellence in research and training of the participating mentors and the proposed multiple disciplinary training. The progress and success of the training program will be evaluated annually by a panel of experts in directing NCI-funded training program. The career development and research activities of trainees will be closely followed up and tracked during the 10 years post-training.