Behavioral Assessment and Medical (BAM) Core

行为评估和医疗（BAM）核心是竞争性TMARC更新的一个新组成部分，它合并了上一个资助期的临床评估和实验室（CAL）和神经精神（NP）核心，以提高资源效率。现在由神经医学和实验室单位（NLU）和神经精神科单位（NPU）组成，BAM核心将通过为TMARC项目和科学核心提供广泛的贡献中心的目标：1）人类参与者的全面神经医学和神经行为表征，2）标本收集/管理，以及3）关于神经医学，实验室，和神经行为数据。标准化的神经医学评估将侧重于受HIV、METH和衰老影响的健康方面，包括参与者的病史和治疗史、神经功能、HIV疾病分期和医疗合并症状态（例如，VACS指数，虚弱）。实验室评估将包括合并感染检测、临床实验室检测（例如，肝转氨酶、血红蛋白）以及脑脊液和血液中反映HIV复制、免疫功能和氧化应激的可溶性和细胞生物标志物。增加了新的生物衰老指标-细胞衰老（端粒缩短）和线粒体衰老（mtDNA损伤），以支持TMARC的衰老主题。NLU还将为TMARC的动物项目提供检测，并支持TMARC的细胞衰老试点项目。NPU将提供全面的神经行为评估，包括神经认知能力、复杂额叶系统行为（冲动/去抑制、感觉寻求和冷漠）、共病精神疾病（情绪、ADHD、ASPD和药物相关），以及关键结果，如ART依从性、危险行为（不安全性行为、药物使用、驾驶）、基于表现的IADL评估、真实的世界功能中的独立性（例如，lADL，就业，健康角色功能），心理社会功能（社会和情感功能，生活质量）和支持TMARC的试点项目，检查新颖的虚拟现实任务的效用，以评估由于METH，HIV和衰老引起的神经行为障碍的日常影响。

The Behavioral Assessment and Medical (BAM) Core is a new component of the competing TMARC renewal, that merges the Clinical Assessment and Laboratory (CAL) and Neuropsychiatric (NP) Cores from the prior funding period to improve resource efficiency. Now comprised of the Neuromedical and Laboratory Unit (NLU) and the Neuropsychiatric Unit (NPU), the BAM Core will extensively contribute to Center objectives by providing to TMARC Projects and Scientific Cores: 1) comprehensive neuromedical and neurobehavioral characterization of human participants, 2) specimen collection/management, and 3) collaboration and training regarding the analyses/interpretation of neuromedical, laboratory, and neurobehavioral data. Standardized neuromedical assessments will focus on aspects of health affected by HIV, METH and aging, including participants' medical and treatment history, neurological functioning, HIV disease staging, and medical comorbidity status (e.g., VACS Index, frailty). Laboratory assessments will include tests for co-infections, clinical lab assays (e.g., hepatic transaminases, hemoglobin), and soluble and cellular biomarkers in cerebrospinal fluid and blood that reflect HIV replication, immune functioning, and oxidative stress. New measures of biologic aging - cell senescence (telomere shortening) and mitochondrial aging (mtDNA injury) are added in support of TMARC's aging theme. The NLU also will provide assays for TMARC's animal projects and support for TMARC's pilot project on cell senescence. The NPU will provide comprehensive neurobehavioral assessments, including neurocognitive abilities, complex frontal systems behaviors (impulsivity/disinhibition, sensation-seeking, and apathy), comorbid psychiatric conditions (mood, ADHD, ASPD, and substance-related), plus key outcomes such as ART adherence, risky behaviors (unsafe sex, drug use, driving), performance-based lADL assessments, independence in real world functioning (e.g., lADLs, employment, health role functioning), psychosocial functioning (social and emotional functioning, quality of life) and support for TMARC's pilot project examining the utility of novel, virtual reality tasks to assess the everyday impact of neurobehavioral impairments due to METH, HIV and aging.