DATA MANAGEMENT AND RESOURCE REPOSITORY FOR THE exRNA ATLAS

描述（由申请人提供）：细胞外rna （exrna）由人体中不同类型的细胞释放到人体血液和其他体液中，并可能被其他细胞吸收。exrna也可能来自可食用植物和居住在人体内的微生物。细胞外RNA通讯计划（ERCP）将探索这种新发现的通讯机制在健康个体和病理条件下，如癌症。exRNA图谱的数据管理资源和存储库（DMRR）将整合FRCP的工作，并作为开发exRNA图谱数据库的社区资源。DMRR将由三个组成部分和一个行政核心组成。数据协调组件（DCC）将制定数据和元数据标准，建立进入exRNA Atlas数据库的数据流；开发用于下载、可视化和分析exRNA数据的工具；并将exRNA Atlas数据库与其他相关资源进行整合。科学外展组件（SOC）将开发exRNA图谱门户网站，传播并提供exRNA图谱数据的可视化；确保使用ercp产生的资源；并利用领先的生物学维基网站发起exRNA生物学的社区参与。SOC将与DCC密切合作，通过举办知识策划讲座、科学研讨会和专题讨论会，吸引社会各界参与。数据集成和分析部分（DIAC）将提供大规模的集成和分析支持；评估由DCC托管的工具和构建管道，用于填充exRNA图谱；构建由DCC部署和分发的工具，供其他联盟参与者和更广泛的科学社区使用exRNA数据；并领导全联盟范围内的先进综合分析。通过DCC、SOC和DIAC组成部分的协调努力，DMRR将帮助组织ERCP联盟，并为新兴的exRNA生物学领域的快速发展提供机会。

DESCRIPTION (provided by applicant): Extra-cellular RNAs (exRNAs) are emitted into the human bloodstream and other body fluids by different types of cells in the human body and may be uptaken by other cells. The exRNAs may also originate from edible plants and from microbes that inhabit the human body. The Extracellular RNA Communication Program (ERCP) will explore this newly discovered mechanism of communication in healthy individuals and in pathological conditions such as cancer. The Data Management Resource and Repository for the exRNA Atlas (DMRR) will integrate the efforts of the FRCP and serve as a community-wide resource for the development of the exRNA Atlas database. DMRR will consist of three components and an Administrative Core. The Data Coordination Component (DCC) will develop data and metadata standards, establish data flow into the exRNA Atlas database; develop tools for download, visualization and analysis of exRNA data; and integrate exRNA Atlas database with other relevant resources. The Scientific Outreach Component (SOC) will develop the exRNA Atlas Web Portal to disseminate and provide for visualization of the exRNA Atlas data; ensure accessibility of ERCP-generated resources; and initiate community engagement in exRNA biology using leading biological Wiki sites. In close coordination with the DCC, the SOC will engage the community through knowledge curation jamborees, scientific workshops and symposia. The Data Integration and Analysis Component (DIAC) will provide large-scale integrative and analytic support; evaluate tools and build pipelines to be hosted by DCC and used to populate the exRNA Atlas; build tools to be deployed and distributed by the DCC for use by other consortium participants and the wider scientific community for exRNA data; and lead consortium-wide advanced integrative analyses. Through these coordinated efforts of its DCC, SOC, and DIAC components, the DMRR will help organize the ERCP consortium and open opportunities for rapid progress in the nascent field of exRNA biology.