Core A - Administrative Core

摘要 行政核心负责指导本计划项目补助金中的所有活动。以下 是行政核心的具体职责： o监督项目资助的所有活动和合作 o每月召开指导委员会会议 o定期召开计划项目调查员会议 o召开外部咨询委员会和内部咨询委员会会议 o汇编和总结所有会议的结果，并将报告分发给方案 项目调查员 o向国家癌症研究所提交年度进展报告 o安排前往3个计划项目地点参加会议 o处理所有计划项目相关费用的报销 o协助计划项目调查人员之间的沟通和报告的准备， 手稿 o与国家癌症研究所项目主任和相关人员进行沟通和讨论 官员 遵守所有大学，NIH和政府法规和要求 o维持财政和预算职能 o结合生物统计核心协调数据质量保证事项 o与共济会癌症分析中心质谱实验室协调 生物化学共享资源 指导委员会由每个项目和核心的主要研究者和合作研究者组成。 外部和内部咨询委员会由杰出的科学家组成，他们以其 在与本计划项目赠款目标高度相关的领域中的杰出工作。行政核心 我将提供专业的协调和监督，以该计划项目赠款的所有活动，以确保 在保持高水平沟通的同时，朝着我们的研究目标顺利合作 我们的研究人员和顾问以及国家癌症研究所，确保遵守所有 法规，并根据需要与所有相关的大学设施，部门和机构合作 及时完成我们的研究 本案无关肺癌是美国和全世界癌症死亡的主要原因。香烟 在美国，吸烟导致大约90%的肺癌死亡率。 最先进的遗传学、表观遗传学、分析化学和生物化学技术， 吸烟者肺癌易感性的种族差异，以揭示关键的机制途径， 为肺癌的预防提供了新的见解。

ABSTRACT The Administrative Core is responsible for direction of all activities in this Program Project Grant. The following are the specific responsibilities of the Administrative Core: o Oversight of all activities and collaborations of the Program Project Grant o Convening monthly meetings of the Steering Committee o Convening regular Program Project Investigators meetings o Convening meetings of the External Advisory Committee and Internal Advisory Committee o Compiling and summarizing the results of all meetings and distributing the reports to Program Project investigators o Preparing annual Progress Reports to the National Cancer Institute o Arranging travel to meetings at the 3 program project sites o Processing reimbursement for all program project-related expenses o Assisting in communication among Program Project investigators and preparation of reports and manuscripts o Communication and discussions with the National Cancer Institute program director and related officials o Compliance with all university, NIH, and governmental regulations and requirements o Maintenance of fiscal and budgetary functions o Coordination of data quality assurance matters in conjunction with the Biostatistics Core o Coordination with the mass spectrometry laboratory of the Masonic Cancer Center Analytical Biochemistry Shared Resource The Steering Committee consists of the Principal Investigators and Co-Investigators of each Project and Core. The External and Internal Advisory Committees consist of distinguished scientists who are well known for their outstanding work in areas highly relevant to the goals of this program project grant. The Administrative Core will provide professional coordination and oversight to all activities of this Program Project grant to ensure smooth collaborative progress toward our research goals while maintaining a high level of communication among our investigators and advisors and the National Cancer Institute, ensuring compliance with all regulations, and working together with all relevant university facilities, departments, and institutes as required for the timely completion of our research. RELEVANCE. Lung cancer is the leading cause of cancer death in the U.S. and worldwide. Cigarette smoking causes approximately 90% of lung cancer mortality in the U.S. This program project grant uses state- of-the-art genetic, epigenetic, analytical chemistry, and biochemical techniques to investigate established ethnic differences in lung cancer susceptibility among smokers to uncover critical mechanistic pathways thus providing new insights for lung cancer prevention.