Oxidative stress as a mediator of environmental exposure impacts on fertility endpoints

该项目扩展了弗格森博士对氧化应激的研究，将其作为一种将环境污染物暴露与不良生殖和妊娠结果联系起来的统一机制。该项目的概念于2016年8月提交给流行病学分支，并获得批准。我们还在选择实验室进行氧化应激指标分析方面取得了进展，并确定了我们将在本研究中使用的受试者和样本采集的具体时间点。在接下来的一年里，我们预计将完成尿液氧化应激生物标志物分析，并发表这项研究的主要结果。

This project extends Dr. Fergusons research into oxidative stress as a unifying mechanism connecting environmental contaminant exposure to adverse reproductive and pregnancy outcomes. The concept for this project was presented to the Epidemiology Branch in August of 2016 and received approval. We have additionally made progress toward selecting a laboratory for analysis of oxidative stress measures, and toward identifying subjects and specific time points of sample collection that we will utilize in the present study. Over the next calendar year we anticipate completion of urinary oxidative stress biomarker analysis and publishing the primary findings from this study.