Summer Training Course in Aging Research

暑期培训课程摘要 要求提供支助，以继续在2008年至2012年期间于6月举办一系列实验性老龄化研究夏季培训班。为期5天的课程将由位于加利福尼亚州诺瓦托的巴克年龄研究所指导，会议地点将在三个主办机构之间轮换：巴克年龄研究所、位于圣安东尼奥的德克萨斯大学健康科学中心和位于西雅图的华盛顿大学。自1993年以来，每年夏天都举办类似的课程，取得了巨大成功。该课程旨在为学员提供密集接触现代研究实验生物学和个性化指导有关的研究思路和计划。每年的招生人数将限制在20名研究人员。大多数学员将在他们的职业生涯的形成阶段，但该课程也将考虑谁希望进入或重新定向他们的努力，以老龄化研究领域的高级研究人员。每个受训者都应在博士学位（MD，PhD或DVM）之外的细胞或分子生物学的某些方面具有至少2年的生产实验室经验。在为期5天的方案中，每天将包括3项活动：（a）2次“概述”讲座，旨在向受训者介绍老年学一个主要领域的背景、最新发现和尚未回答的主要问题;（B）一次研究发展讲习班，每个受训者将有机会提出自己的研究想法和计划，供评论;及（c）由主办机构或邻近机构的杰出教职员主讲的研究研讨会，该名教职员一般会涉及概述讲座中未涵盖的课题或疾病方面。这个暑期培训课程将为年轻的研究人员提供现代实验老年学的坚实基础，并为正在开发衰老研究新项目的资深科学家提供有用的视角。 四位科学家将担任课程指导委员会，并将定期参加课程：课程主任Judith Campisi将讨论癌症，干细胞和衰老的细胞生物学; Jan Vijg将讲授衰老和基因组不稳定性的小鼠模型; Arlan Richardson将讨论热量限制和氧化应激; Peter Rabinovich将讲授自由基和线粒体。其他14名研究人员将担任参与教师，参加课程大约每三年。它们包括：安杰伊·巴特克（老化的内分泌学），布赖恩肯尼迪（无脊椎动物模型，热量限制），Caleb Finch（神经变性，随机性），乔治马丁（早老症、神经变性、年龄相关疾病），Gordon利斯戈（无脊椎动物模型，压力），吉姆纳尔逊（内分泌学，压力），约翰塔（无脊椎动物模型，性别决定），马克·塔塔尔（demography，evolution），Nir Barzilai（遗传变异），理查德米勒（脊椎动物模型，免疫学），丽塔·埃弗罗斯（免疫学，细胞生物学），史蒂夫·奥斯塔德（比较生物学，进化），汤姆·兰多（干细胞，细胞生物学），弗吉尼亚·李（神经变性）。

SUMMER TRAINING COURSE ABSTRACT Support is requested to continue a series of Summer Training Courses in Experimental Aging Research to be held in June from 2008 through 2012. The 5-day Course will be directed from the Buck Institute for Age Research in Novato, CA and the conference site will rotate among three host institutions: The Buck Institute for Age Research, the University of Texas Health Science Center at San Antonio, and the University of Washington in Seattle. Similar courses have been held with great success every summer since 1993. The Course is designed to provide trainees with intensive exposure to modern research in experimental biogerontology and individualized guidance regarding research ideas and plans. Each year's enrollment will be limited to 20 researchers. Most trainees will be in formative stages of their careers, but the Course will also consider senior investigators who wish to enter or redirect their efforts to an area of aging research. Each trainee is expected to have at least 2 years of productive laboratory experience in some aspect of cell or molecular biology beyond the doctoral degree (MD, PhD, or DVM). Each day during the 5-day program will include 3 activities: (a) 2 "overview" lectures designed to introduce trainees to the context, latest findings and main unanswered questions in a major area of gerontology; (b) a research development workshop, at which each trainee will have an opportunity to present his or her own research ideas and plans for critique; and (c) a research seminar presented by a prominent faculty member of the host or nearby institution, who will generally cover a topic or disease aspect not covered in the overview lectures. This Summer Training Course will provide younger researchers with a solid foundation in modern experimental gerontology, and provide a useful perspective to more senior scientists who are developing new programs in aging research. Four scientists will serve as the Course Steering Committee and will participate in the course on a regular basis: Judith Campisi, the Course Director, will discuss cancer, stem cells and the cell biology of aging; Jan Vijg will lecture on mouse models of aging and genome instability; Arlan Richardson will discuss on caloric restriction and oxidative stress; and Peter Rabinovich will lecture on free radicals and mitochondria. Fourteen other researchers will serve as Participating Faculty, attending the course approximately every third year. They include: Andrzej Bartke (endocrinology of aging), Brian Kennedy (invertebrate models, caloric restriction), Caleb Finch (neurodegeneration, stochasticity), George Martin (progerias, neurodegeneration, age-related disease), Gordon Lithgow (invertebrate models, stress), Jim Nelson (endocrinology, stress), John Tower (invertebrate models, sex determination), Marc Tatar (demography, evolution), Nir Barzilai (genetic variation), Richard Miller (vertebrate models, immunology), Rita Effros (immunology, cell biology), Steve Austad (comparative biology, evolution), Tom Rando (stem cells, cell biology), Virginia Lee (neurodegeneration).