Phagocytic clearance and immune activation in malaria

巨噬细胞白细胞通过三种途径清除感染疟疾的细胞--通过识别细胞表面的抗体或补体，或者通过细胞直接与巨噬细胞结合。每一种都有不同的结果，比如产生的细胞因子的数量。细胞因子可以清除疟疾；过量的细胞因子会导致致命的免疫病理。我们将研究疟疾感染细胞中抗体和补体的数量和摄取途径的变化如何决定疟疾的结果。

Macrophage white blood cells clear malaria infected cells by eating them, by three routes- by recognising ANTIBODIES or COMPLEMENT on the cell surface, or by the cell BINDING directly to the macrophage. Each has different results, such as amounts of cytokines produced. Cytokines clear malaria; in excess they can cause fatal immune pathology. We will investigate how variations in amount of antibody and complement and route of uptake of malaria infected cells might determine malaria outcome.