An investigation into pathogen-specific factors required for drug-resistance and viability of Candida albicans

我们确定了白色念珠菌生长和耐药性所需的蛋白质，白色念珠菌是一种主要的医院获得性人类病原体。念珠菌感染的目标是免疫功能低下的人，死亡率很高(30%-50%)。我们将使用细胞生物学、遗传学和生物化学来描述这些蛋白质。重要的是，这些因素在真菌中存在，但在人类中不存在。因此，我们的研究将有助于开发新的抗真菌治疗策略。

We identified proteins required for growth and drug resistance of the fungus Candida albicans, a major hospital-acquired human pathogen. Candida infections target the immunocompromised and mortality is huge (?30-50%). We will use cell biology, genetics and biochemistry to characterise these proteins. Importantly, these factors are present in fungi, but absent from humans. Therefore our study will help development of new strategies for antifungal treatments.