THE CYCLE OF OBESITY: Two generations of a pregnancy cohort to investigate obesity epigenetics

在过去的50年里，肥胖增加了3-5倍，超过吸烟成为最大的杀手。在最近的历史中，每一代人都经历了更严重的肥胖，而且年龄更小。在子宫里暴露在母亲的肥胖环境中，可能会通过改变我们的表观遗传特征和解读DNA密码的方式，将风险传递给孩子。我们需要打破这种恶性循环。这项研究是世界上第一次调查两代人的肥胖和表观遗传特征。

Obesity has increased 3-5 fold in the last fifty years, overtaking smoking as the greatest killer. In recent history, each generation has experienced greater amounts of obesity and at younger ages. Being exposed in the womb to mother’s obesity transmits the risk to the child, possibly by changing our epigenetic profile and how our DNA code is read. We need to break this vicious cycle. This study is a world first, investigating 2 generations with respect to obesity and epigenetic profiles.