The genetic basis of pathogen blocking: elucidating the contributions of the Wolbachia, dengue virus and mosquito genomes

一种名为沃尔巴克氏体的细菌已被证明可以阻止登革热病毒在蚊子体内复制，因此正在作为登革热的生物防治剂进行实地试验。对这一战略的一个主要威胁是蚊子或病毒出现耐药性。这一建议解决了两个基本的知识空白——沃尔巴克氏体如何阻止病毒生长以及耐药性如何演变？这项研究具有重要意义，因为它将为制定对抗耐药性的战略提供信息。

A bacterium called Wolbachia has been shown to stop dengue virus from replicating inside mosquitoes and so is being field-tested as a biocontrol agent against dengue fever. A major threat to this strategy is the emergence of resistance either in the mosquito or virus. This proposal addresses two fundamental knowledge gaps – how does Wolbachia block virus growth and how might resistance evolve? This research is significant as it will inform the development of strategies to counter resistance.