The neural reaction to injury: Clues to the cause and prevention of acquired brain damage and Alzheimer's disease.

脑外伤和阿尔茨海默病后神经元变性的细胞机制？S疾病尚不清楚，是开发保护神经细胞的治疗策略的主要障碍。这项拨款申请将利用各种现代研究方法来确定大脑中与神经细胞对物理创伤的反应相关的关键变化。这些变化不仅包括损伤后立即发生的结构变化，还包括决定细胞最终命运的复杂细胞和基因表达变化。获得性脑损伤和退行性疾病，如阿尔茨海默病？这种疾病构成了巨大的健康、社会和经济负担。此外，预测阿尔茨海默病？到下个世纪中叶，由于老龄化，该病将增加3-4倍。在人口中，建立有效的治疗干预措施变得更加重要。在这个项目中研究的动物模型可以用来揭示与头部创伤和阿尔茨海默病早期阶段相关的关键神经元改变。更重要的是，它可能是发现预防这些疾病中神经元退化的新策略的关键。

The cellular mechanism underlying neuronal degeneration following head trauma and Alzheimer?s disease is not known and represents the major impediment to developing therapeutic strategies to protect nerve cells. This grant application will utilise a variety of modern research methods to determine the key changes in the brain that are associated with the response of nerve cells to physical trauma. These include not only the structural alterations that immediately follow such injury, but the complex cellular and gene expression changes that determine the ultimate fate of the cell. Both acquired brain injury and degenerative conditions such as Alzheimer?s disease represent an enormous health, social and economic burden. Furthermore, with predictions that Alzheimer?s disease will increase by 3-4 times by the middle of the next century due to the Oaging? of the population, it is becoming even more crucial to establish effective therapeutic interventions. The animal models investigated in this project can be used to unravel the crucial neuronal alterations associated with head trauma and the early stages of Alzheimer?s disease and, more importantly, may be the key to discovering novel strategies to prevent neuronal degeneration in these conditions.