Bacterial Pathogenomics: whole-genome sequencing to investigate infection transmission, pathogenesis and antibiotic resistance

由于对多种抗生素具有抗药性的超级细菌占据了新闻头条，新抗生素的研发渠道几乎已经枯竭。高通量DNA测序预示着传染病研究的黄金机会。通过研究大量耐多药细菌菌株的整个基因集合——基因组，我们的目标是更好地理解控制超级细菌出现和全球传播的遗传变化，并将这些发现转化为临床。

As bacterial superbugs – resistant to multiple antibiotics – dominate the headlines, the pipeline for new antibiotics has all but dried up. High-throughput DNA sequencing heralds a golden opportunity for infectious disease research. By studying the entire collection of genes - the genome - of large numbers of multidrug resistant bacterial strains, we aim to better understand the genetic changes that govern the emergence and global spread of superbugs and translate these findings into the clinic.