Central Mechanisms Influencing Hypertension

本研究旨在探讨应激相关性高血压的重要中枢机制。我的团队将专注于组织纤溶酶原激活剂在介导慢性应激对神经可塑性的抑制作用中的作用，并研究gaba能和一氧化氮通路中的抑制功能障碍，这些通路导致交感神经活动增加和血压升高。重要的是，我们将研究针对每一种高血压疗法的三种干预措施的潜力。

This proposal aims to examine central mechanisms important in stress related hypertension. My team will focus on the role of tissue plasminogen activator in mediating inhibitory effects of chronic stress on neural plasticity and examine inhibitory dysfunction in GABAergic and nitric oxide pathways that lead to increased sympathetic activity and elevated blood pressure. Importantly, we will investigate the potential of three interventions directed at each as therapies for hypertension.