Engineering defects in SAMs of alkylthiols for improved biosensing strategies

生物传感器是一类被设计成在给定环境中识别目标生物分子的装置。它们已在医学界用于疾病的早期检测和治疗，但作为检测生物战剂的方法也是可取的。因此，传感器的属性通常包括小型化尺寸、高特异性、多功能性和不存在假阳性。随着传感器需求的不断变化，用于传感器材料的创建和表征的新方法正在进行中。通常，生物识别事件是基于与底物的分子结合，并且存在表面改性策略以用特定受体基团官能化材料。为了增强可能的多功能性，需要多种受体基团，并且通过表面图案化方法使其成为可能。我们的研究重点是使用电化学技术来独特地设计和表征涂覆有图案化几何形状的有机受体材料的表面。我们将结合联合收割机我们的经验与表面图案的散装表面装饰金纳米粒子以类似的方式。将该装置耦合到表面等离子体共振光谱（SPR）的光谱方法将增强我们的检测方案，超越典型的SPR调查。

Biosensors are a class of device engineered to recognize a target biomolecule in a given environment. They have been used in the medical community for the early detection and treatment of disease but are also desirable as methods of detecting biological warfare agents. As such, the attributes of a sensor often include minaturized size, high specificity, multi-functionality and the absence of false positives. With the ever changing requirements of the sensor, new methods for the creation and characterization of the sensor material are ongoing. Typically the bio-recognition event is based on molecular binding with a substrate and surface modification strategies exist to functionalize the material with specific receptor groups. To enhance possible multi-functionality, a variety of receptor groups is desirable and is made possible through surface patterning methods. Our research focuses on the use of electrochemical techniques to uniquely design and characterize a surface coated with organic-receptor materials in a patterned geometry. We will combine our experience with surface patterning of bulk surfaces to decorate gold nanoparticles in a similar manner. Coupling the device to a spectroscopic method of Surface Plasmon Resonance Spectroscopy (SPR) will enhance our detection schemes beyond typical SPR investigations.