Regulation of natural killer cell homeostasis by multiple components of the immune system

免疫细胞群如CD4和CD8T细胞以及树突状细胞的分化和动态平衡一直是了解它们在炎症过程中功能的关键。相比之下，晚期自然杀伤(NK)细胞分化在很大程度上被忽视了。鉴于NK细胞在提供先天效应免疫和形成适应性反应方面的关键作用，更好地理解调节其分化的线索显然是有必要的。

Differentiation and homeostasis of immune cell populations such as CD4 and CD8 T cells and dendritic cells has been key to understanding their function during inflammation. In contrast, late stage natural killer (NK) cell differentiation has largely been ignored. Given the key role of NK cells in providing innate effector immunity and shaping adaptive responses, a better understanding of the cues that regulate their differentiation is clearly warranted.