Ultracentrifuge and rotors

随着人们对禽流感爆发导致另一场人类大流行的新恐惧，了解病毒如何与宿主相互作用、传播以及它们如何变化变得越来越重要。从东道国的角度来看，同样重要的是开发程序、疫苗和诊断试剂，以帮助减少包括流感病毒在内的病毒性疾病的发病率和传播。我们的研究小组致力于解决病毒（例如鸡的禽腺病毒）和细菌（例如牛的溶血性曼氏杆菌）如何在动物中引起疾病的问题，并开发针对它们和其他微生物的有效疫苗。超离心是分离和浓缩整个微生物和/或其组分的基本技术。这种方法是不可替代的，因此离心机是任何研究实验室的必要设备。本提案中要求的超浓缩物将为7名研究人员提供服务，并将由申请人（和部门内其他人员）及其实验室人员常规使用，以实现其在兽医病毒学、细菌学、免疫学和疫苗学领域的研究目标。 在不同层次的培训（研究生和本科生课程）中也需要超强度培训。

With the renewed fears of an avian influenza outbreak resulting in another human pandemic, it is becoming increasingly important to understand how viruses interact with their host, are transmitted and how they might change. Equally important, from the host point of view, is to develop procedures and vaccines and diagnostic reagents which can help reduce the incidence and spread of viral diseases, including influenza viruses. Our research groups are working on to address the questions how viruses (for example fowl adenovirus of chickens) and bacteria (for example Mannheimia haemolytica in cattle) can cause disease in animals and on developing efficacious vaccines against them and other microbes.Ultracentrifugation is a basic technique for separation and concentration of whole microorganisms and/or their components. The methodology cannot be substituted therefore centrifuges are essential equipment to any research laboratory. The ultracentrifuge requested in this proposal will serve a group of 7 researchers and will be used routinely by the applicants (and others in the Department) and their laboratory personnel to achieve their research goals in the area of veterinary virology, bacteriology, immunology and vaccinology.  The ultracentrifuge is also needed at different levels of training (graduate and undergraduate programs).