Research Fellowship

血小板是防止因受伤或感染而出血的关键血液成分。过度活跃或自发活跃的血小板会导致血栓形成和血栓形成。我的实验室已经发现了激活血小板金属蛋白酶的新的生理途径，这种酶调节血栓前血小板受体的表面水平。通过了解受体调节的这一机制，我们可以针对血栓前病变患者的血小板受体进行独特的靶向。

Platelets are key blood elements that are essential for the prevention of bleeding in response to injury or infection. Overactive or spontaneously active platelets cause thrombosis and blood clot formation. My laboratory has identified new physiological pathways of activation of platelet metalloproteinases, the enzymes that regulate surface levels of the prothrombotic platelet receptors. By understanding this mechanism of receptor regulation, we can uniquely target platelet receptors in people with prothrombotic pathologies.