RNA Polymerase I: A novel target in the treatment of MYC driven malignancies

核糖体（细胞蛋白质合成机器）的合成在癌症期间失调，导致其可能是恶性过程的病因的假设。本申请将使用新型抑制剂或核糖体生物合成在称为E-MYC的小鼠遗传模型中测试这一假设，该模型忠实地复制了人类B细胞淋巴瘤。这些研究将揭示恶性转化的新机制，并确定治疗人类癌症的新疗法。

Synthesis of ribosomes, the cellular protein synthetic machinery, is dysregulated during cancer leading to the hypothesis that it may be causative in the malignant process. This application will test this hypothesis using novel inhibitors or ribosome biogenesis in a mouse genetic model termed E�-MYC that faithfully that replicates human B-cell lymphoma. These studies will uncover novel mechanisms in malignant transformation and identify new therapeutics in the treatment of human cancer.