Role of exported proteins in malaria parasite development in the liver

每年有超过2.5亿人感染疟疾，超过100万人死亡。疟疾寄生虫成功的关键是在宿主细胞内生活的能力，包括肝细胞和红细胞。在这里，我们的目标是确定疟疾寄生虫如何在肝细胞内生活，设计不再能做到这一点的突变寄生虫，并评估突变寄生虫是否对未来的疟疾具有保护作用。我们的计划将使用毒力最强的人类寄生虫恶性疟原虫和啮齿动物寄生虫P.berghei。

Each year over 250 million people contract malaria and over 1 million die. The key to the malaria parasite’s success is the ability to live inside host cells, including hepatocytes and erythrocytes. Here, we aim to determine how the malaria parasite lives within hepatocytes, to engineer mutant parasites that can no longer do so and to assess whether mutant parasites confer protection against future malaria. Our program will use the most virulent human parasite P. falciparum and the rodent parasite P. berghei.