The role of Kdm1a in epigenetic regulation of virus-specific T cell differentiation.

从感染中恢复，或接种疫苗，可以建立保护性免疫，这种免疫可以持续一生。不幸的是，我们对感染或接种疫苗后保护性免疫是如何建立和维持的了解不足。这一提议将确定参与重写遗传蓝图的特定酶是否是建立和维持这种保护能力的关键。了解这些机制对疫苗接种和改进癌症免疫治疗策略具有重要意义。

Recovery from infection, or vaccination, results in the establishment of protective immunity that persists for the life of an individual. Unfortunately, our understanding of how protective immunity is established and maintained after infection or vaccination is lacking. This proposal will determine whether specific enzymes involved in rewriting the genetic blueprint are key for establishing and maintaining this protective capacity. Understanding these mechanisms has implications for vaccination and improved immunotherapy strategies for cancer.