New methods for the synthesis of biaryl compunds

联芳基结构基元的应用促进了针对高效和高产率合成方法的开发的密集研究。过渡金属催化在这些努力中发挥了突出作用，导致了一系列有用的交叉偶联反应的建立。所有这些过程中的一个共同要素是需要两个活化的芳烃，它们可以选择性地与金属催化剂反应。虽然用预活化的基板可以实现高产量，但双重预活化的需要本身就是浪费的，因为这些组可能需要多个步骤来安装。此外，并不是所有的有机金属或芳基卤化物的区域异构体都很容易获得，这使得一些联芳基化合物很难获得。在某些情况下，预活化物种可能不稳定，从而使这一方法的应用复杂化。这项建议的目标是开发新的金属催化反应，以制备需要较少或不需要预活化步骤的联芳基分子。一旦成功，新反应将在这类重要化合物的制备中得到重要应用。

The utility of the biaryl structural motif has prompted intense research directed at the development of efficient and high yielding synthetic methods. Transition metal catalysis has featured prominently in these efforts, leading to the establishment of a range of useful cross coupling reactions. A common element in all of these processes is the need for two activated arenes that can react selectively with the metal catalyst. While high yields can be achieved with pre-activated substrates, the need for dual pre-activation is inherently wasteful since these groups may require multiple steps for their installation. Furthermore, not all regioisomers of the organometallic or aryl halide are readily available making some biaryl compounds difficult to access. In some instances the pre-activated species may not be stable thus complicating application of this methodology. This proposal targets the development of new metal catalyzed reactions for the preparation of biaryl molecules that require less, or no pre-activation steps. Once successful, the new reactions should find significant application in the preparation of this important class of compound.