Social behaviour in rats developmentally deficient in Vitamin D: Modelling the negative symptoms of schizophrenia
Social behaviour in rats developmentally deficient in Vitamin D: Modelling the negative symptoms of schizophrenia
批准号:
nhmrc : 511066
负责人:
A/Pr Thomas Burne
金额:
$24.07万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2012-12-31
中文摘要
我们正在探索低母亲维生素D作为一种生物学解释,以解释全球范围内一年中较冷的月份出生的精神分裂症患者发病率增加7%-10%的原因。大鼠发育性维生素D(DVD)缺乏会导致大脑发育和行为的长期变化。这项研究的目的是检测dvd缺乏的大鼠的社会行为,作为精神分裂症阴性症状的模型,并建立这种行为改变的神经化学基础。
英文摘要
We are exploring low maternal vitamin D as a biological explanation for a 7-10% increase in the incidence of patients born with schizophrenia in the colder months of the year world wide. Developmental vitamin D (DVD) deficiency in rats leads to long term changes in brain development and behaviour. The aim of this research is to examine social behaviour in DVD deficient rats as a model of negative symptoms of schizophrenia and establish the neurochemical basis for this altered behaviour
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