Specialised subsets of T follicular helper cells in the control of infection and immune pathology

抗体的缺陷或不受控制的产生会增加感染、过敏和自身免疫性疾病的易感性。一种称为滤泡辅助细胞(TFH)的T细胞已经成为保护性抗体和病理性抗体产生的关键控制者。我们有数据表明，有专门的TFH亚群，每个亚群控制着抗体反应的不同阶段和结果。确定每个亚群的调控和功能将为治疗这些慢性衰弱疾病提供新的靶点。

Defective or uncontrolled production of antibodies leads to increased susceptibility to infection, allergies, and autoimmune diseases. A type of T cell called follicular helper (Tfh) has emerged as a key controller of both protective and pathologic antibody production. We have data suggesting there are specialised Tfh subsets, each controlling different stages and outcomes of antibody responses. Identifying how each subset is regulated and functions will provide novel targets to treat these chronic debilitating diseases.