Sphingosine kinase as a target therapeutic for obesity induced insulin resistance

肥胖与胰岛素抵抗和糖尿病的发展有关，这在澳大利亚是一个重大的健康问题。许多因素导致胰岛素抵抗的发展，包括脂肪酸代谢缺陷。本研究拟探讨是否操纵鞘氨醇激酶，在脂质代谢的关键酶，影响胰岛素抵抗的发展。这些研究可能会发现治疗胰岛素抵抗和糖尿病的新靶点。

Obesity is linked to the development of insulin resistance and diabetes, which represent a significant health issue in Australia. A number of factors contribute to the development of insulin resistance, including defective fatty acid metabolism. This study proposes to investigate whether manipulating sphingosine kinase, a key enzyme in lipid metabolism, affects the development of insulin resistance. These studies may identify novel targets for the treatment of insulin resistance and diabetes.