The structural basis for promiscuity of drug binding to hERG K+ channels

一种叫做离子通道的特殊蛋白质控制着心脏的电活动。阻断离子通道的药物可能会产生不良的副作用，改变心跳的节奏，导致心脏性猝死。在药物开发期间，人们已经做出了广泛的努力来筛查这个问题，但这仍然是一门不精确的科学。在这里，我们将使用高分辨率成像技术来更好地了解药物如何与离子通道蛋白结合。

Special proteins called ion channels control the electrical activity of the heart. Drugs that block ion channels can have the unwanted side-effect of altering the rhythm of the heart beat and causing sudden cardiac death. Extensive efforts are made to screen for this problem during drug development but it is still an inexact science. Here we will use high resolution imaging technologies to get a better understanding of how drugs bind to ion channel proteins.