Systems approaches to understanding the assembly of mitochondrial machines

线粒体为我们的身体提供能量。这个过程中的缺陷会导致线粒体疾病，至少有1/5000人会受到影响。诊断通常是不确定的，因为我们不了解线粒体能量生产中许多重要蛋白质的功能。最先进的CRISPR基因编辑工具将与先进的蛋白质组学技术相结合，以模拟不同类型的线粒体疾病，并确定新的候选疾病基因的功能。

Mitochondria produce the energy for our bodies. Defects in this process cause mitochondrial disease, which affects at least 1/5000 people. Diagnosis is often inconclusive as we do not understand the function of many proteins important in mitochondrial energy production. State of the art CRISPR gene-editing tools will be coupled with advanced proteomics techniques to model different types of mitochondrial disease and identify the functions of new candidate disease genes.