Targeting of callosal axons to duplicate cortical areas in the contralateral hemisphere
Targeting of callosal axons to duplicate cortical areas in the contralateral hemisphere
批准号:
nhmrc : 1064174
负责人:
Prof Linda Richards
金额:
$40.06万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31
中文摘要
大脑的两侧通过一个叫做胼胝体的大纤维束进行交流。本研究旨在探讨胼胝体在胚胎和出生后发育过程中是如何形成的。具体来说,我们研究了构成胼胝体的轴突如何能够在对侧半球定位其精确的目标,以便它们形成的大脑回路发挥作用。我们开发了一种新的小鼠模型,以发现调节大脑如何连接以正确运作的基本机制。
英文摘要
The two sides of the brain communicate via a large fibre tract called the corpus callosum. This proposal investigates how the corpus callosum is formed during embryonic and postnatal development. Specifically, we investigate how the axons that make up the corpus callosum are able to locate their precise target in the contralateral hemisphere so that the brain circuit they form will be functional. We have developed a new mouse model to discover the fundamental mechanisms regulating how the brain is wired in order to function correctly.
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会议论文
Corpus callosum function in decision making
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批准号:DP210101712
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项目类别:Discovery Projects
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资助金额:$10.12万
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财政年份:2021
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负责人:Prof Linda Richards
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依托单位:
Control of cellular differentiation in the developing brain
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批准号:DP200102363
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项目类别:Discovery Projects
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资助金额:$30.66万
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财政年份:2020
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负责人:Prof Linda Richards
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依托单位:
Normal and abnormal development of brain wiring and its impact on brain function
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批准号:nhmrc : GNT1120615
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项目类别:Research Fellowships
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资助金额:$76.38万
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财政年份:2017
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负责人:Prof Linda Richards
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依托单位:
Normal and abnormal development of brain wiring and its impact on brain function
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批准号:nhmrc : 1120615
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项目类别:Research Fellowships
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资助金额:$52.22万
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财政年份:2017
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负责人:Prof Linda Richards
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依托单位:
Unravelling the principles of bilateral brain wiring
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批准号:DP160103958
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项目类别:Discovery Projects
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资助金额:$41.86万
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财政年份:2016
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负责人:Prof Linda Richards
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依托单位:
Early formation of the preplate establishes the cerebral cortex
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批准号:DP140101499
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项目类别:Discovery Projects
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资助金额:$47.45万
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财政年份:2014
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负责人:Prof Linda Richards
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依托单位:
Cellular and molecular regulation of interhemispheric fusion
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批准号:nhmrc : 1048849
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项目类别:Project Grants
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资助金额:$29.97万
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财政年份:2013
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负责人:Prof Linda Richards
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依托单位:
Guidance mechanisms regulating the development of axonal projections from the cingulate cortex.
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批准号:nhmrc : 1043045
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项目类别:Project Grants
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资助金额:$32.29万
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财政年份:2013
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负责人:Prof Linda Richards
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依托单位:
Molecular and activity dependent mechanisms regulating the targeting of corpus callosum axons in the contralateral hemisphere.
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批准号:nhmrc : 1029975
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项目类别:Project Grants
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资助金额:$27.56万
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财政年份:2012
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负责人:Prof Linda Richards
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依托单位:
Development of the cerebral cortex
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批准号:nhmrc : 1005751
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项目类别:Research Fellowships
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资助金额:$58.7万
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财政年份:2011
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负责人:Prof Linda Richards
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依托单位:
DCC-Robo interactions cooperate to regulate callosal axon guidance
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批准号:nhmrc : 631466
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项目类别:NHMRC Project Grants
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资助金额:$25.57万
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财政年份:2010
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负责人:Prof Linda Richards
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依托单位:
Specialized glial cells within the hippocampus of the brain regulate important morphological events in embryonic development
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批准号:DP0984643
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项目类别:Discovery Projects
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资助金额:$54.32万
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财政年份:2009
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负责人:Prof Linda Richards
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依托单位:
Nuclear Factor One genes regulate multiple aspects of cerebral cortex development
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批准号:nhmrc : 569504
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项目类别:NHMRC Project Grants
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资助金额:$35.13万
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财政年份:2009
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负责人:Prof Linda Richards
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依托单位:
The role of Netrin-DCC in the development of the corpus callosum
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批准号:nhmrc : 456026
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项目类别:NHMRC Project Grants
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资助金额:$34.14万
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财政年份:2007
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负责人:Prof Linda Richards
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依托单位:
Development of the commissural plate and its role in forebrain commissure development
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批准号:nhmrc : 456027
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项目类别:NHMRC Project Grants
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资助金额:$35.31万
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财政年份:2007
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负责人:Prof Linda Richards
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依托单位:
Advanced Cell Labelling and Imaging Facility
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批准号:LE0668246
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$26.67万
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财政年份:2006
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负责人:Prof Linda Richards
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依托单位:
Regulation of cortical development by Nfi genes.
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批准号:nhmrc : 401616
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项目类别:NHMRC Project Grants
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资助金额:$31.49万
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财政年份:2006
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负责人:Prof Linda Richards
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依托单位:
Research Fellowship - Grant ID:401658
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批准号:nhmrc : 401658
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项目类别:NHMRC Research Fellowships
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资助金额:$40.48万
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财政年份:2006
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负责人:Prof Linda Richards
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依托单位:
海外基金