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Targeting glycointeractions to generate new opportunities to treat and prevent bacterial infections.

Targeting glycointeractions to generate new opportunities to treat and prevent bacterial infections.
针对糖相互作用创造治疗和预防细菌感染的新机会。
批准号:
nhmrc : 1138466
负责人:
Prof Michael Jennings
金额:
$52.37万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2022-12-31

项目摘要

项目成果

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中文摘要
翻译
细菌和细菌毒素可以与人体细胞上称为聚糖的复杂糖结构相互作用。我的研究小组已经确定了细菌使用的新的和重要的聚糖相互作用,这些相互作用导致了从肺炎、脑膜炎、食源性感染到尿路和性传播疾病的疾病。既然这些相互作用已经被发现,就可以利用它们来制造药物和疫苗,通过阻断聚糖相互作用来治疗和预防疾病。
英文摘要
Bacteria and bacterial toxins can interact with complex sugar structures on human cells called glycans. My research team has identified new and important glycan interactions used by bacteria that cause diseases ranging from pneumonia, meningitis and food borne infections to urinary tract and sexually transmitted diseases. Now that these interactions have been discovered, they can be exploited to create drugs and vaccines that may treat and prevent disease by blocking the glycan interactions.
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A “Goldilocks” live attenuated poultry vaccine for Infectious Coryza
  • 批准号:
    LP210301365
  • 项目类别:
    Linkage Projects
  • 资助金额:
    $44.35万
  • 财政年份:
    2023
  • 负责人:
    Prof Michael Jennings
  • 依托单位:
Genetic Basis of Variable Expression of Glycan Xeno-Autoantigens by Cattle
  • 批准号:
    DP200103734
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $33.72万
  • 财政年份:
    2020
  • 负责人:
    Prof Michael Jennings
  • 依托单位:
Targeting glycointeractions to generate new opportunities to treat and prevent bacterial infections.
  • 批准号:
    nhmrc : GNT1138466
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $77.45万
  • 财政年份:
    2018
  • 负责人:
    Prof Michael Jennings
  • 依托单位:
Glycointeractions
  • 批准号:
    DP170104692
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $32.38万
  • 财政年份:
    2017
  • 负责人:
    Prof Michael Jennings
  • 依托单位:
海外基金